Welcome to LookChem.com Sign In|Join Free

Home > Products > 1082041-53-9

6-Iodo-3-methyl-1H-indazole is an indazole derivative with the molecular formula C9H8IN, featuring an iodo group at the 6th position and a methyl group at the 3rd position. This chemical compound has garnered interest in medicinal chemistry and research due to its potential pharmaceutical applications, particularly in the development of new drugs. Indazole derivatives are known for their diverse biological activities, such as anti-inflammatory, anti-cancer, and anti-microbial properties. The unique substitution pattern in 6-Iodo-3-methyl-1H-indazole may enhance its pharmacological properties and contribute to its therapeutic benefits. Moreover, the presence of an iodo group also renders 6-Iodo-3-methyl-1H-indazole valuable for labeling studies in biochemistry and molecular biology.

1082041-53-9

Post Buying Request

Basic information
1. Product Name: 6-Iodo-3-methyl-1H-indazole
2. Synonyms: 6-Iodo-3-methyl-1H-indazole;6-Iodo-3-Methyl-1H-indazo...;1H-Indazole, 6-iodo-3-Methyl-
3. CAS NO:1082041-53-9
4. Molecular Formula: C8H7IN2
5. Molecular Weight: 258.05905
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 1082041-53-9.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: /
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: N/A
9. CAS DataBase Reference: 6-Iodo-3-methyl-1H-indazole(CAS DataBase Reference)
10. NIST Chemistry Reference: 6-Iodo-3-methyl-1H-indazole(1082041-53-9)
11. EPA Substance Registry System: 6-Iodo-3-methyl-1H-indazole(1082041-53-9)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 1082041-53-9(Hazardous Substances Data)

Suppliers
Usage
SDS
Synthetic route
Upstream product
Downstream Products

1082041-53-9 Suppliers

Recommended suppliers

1082041-53-9 Usage

Uses

Used in Pharmaceutical Industry:
6-Iodo-3-methyl-1H-indazole is used as a pharmaceutical candidate for the development of new drugs, leveraging its potential anti-inflammatory, anti-cancer, and anti-microbial properties. The structural modifications introduced in the indazole core may enhance its therapeutic efficacy and selectivity.
Used in Medicinal Chemistry Research:
6-Iodo-3-methyl-1H-indazole serves as a valuable compound in medicinal chemistry research, where it can be further modified and optimized to discover novel drug candidates with improved pharmacological profiles.
Used in Biochemistry and Molecular Biology:
6-Iodo-3-methyl-1H-indazole is used as a labeling agent in biochemistry and molecular biology studies, taking advantage of the iodo group for easy detection and tracking of biomolecules in various experimental setups.

Check Digit Verification of cas no

The CAS Registry Mumber 1082041-53-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,2,0,4 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1082041-53:
(9*1)+(8*0)+(7*8)+(6*2)+(5*0)+(4*4)+(3*1)+(2*5)+(1*3)=109
109 % 10 = 9
So 1082041-53-9 is a valid CAS Registry Number.

1082041-53-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name	6-iodo-3-methyl-2H-indazole

1.2 Other means of identification

Product number	-
Other names	1H-INDAZOLE,6-IODO-3-METHYL

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1082041-53-9 SDS

1082041-53-9Synthetic route

: 110-87-2
3,4-dihydro-2H-pyran

: 1082041-53-9
C8H7IN2

: 6-iodo-3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Conditions

Conditions	Yield
With methanesulfonic acid In tetrahydrofuran at 80℃; for 8h; Inert atmosphere;	81%

: 1082041-53-9
C8H7IN2

: 2533-69-9
methyl 2,2,2-trichloroacetimidate

: 1234616-58-0
6-iodo-2,3-dimethyl-2H-indazole

Conditions

Conditions	Yield
Stage #1: C8H7IN2 With trifluorormethanesulfonic acid In dichloromethane at 25 - 35℃; Inert atmosphere; Stage #2: methyl 2,2,2-trichloroacetimidate In dichloromethane at 20℃; Inert atmosphere; regioselective reaction;

: 1082041-53-9
C8H7IN2

: 3-((3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)thio)propanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere 3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 3 steps
1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere
3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
View Scheme

: 1082041-53-9
C8H7IN2

: 3-((3-methyl-1H-indazol-6-yl)thio)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)propanamide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere 3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C 5: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere
3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C
5: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
View Scheme

: 1082041-53-9
C8H7IN2

: methyl 3-((3-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)thio)propanoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere View Scheme

: 1082041-53-9
C8H7IN2

: C29H36F3N5O2S

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere 3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme

Yield

Multi-step reaction with 4 steps
1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere
3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C
View Scheme

1082041-53-9Upstream product

1082041-53-9Downstream Products

1234616-58-0 6-iodo-2,3-dimethyl-2H-indazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 1082041-53-9

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

[Hangzhou]86-0571-87562588,87562578,87562573 Our Legal adviser: Lawyer

1082041-53-9

Basic information

Chemical Properties

Safety Data

1082041-53-9 Suppliers

Recommended suppliers

1082041-53-9 Usage

Uses

Check Digit Verification of cas no

1082041-53-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

1082041-53-9Synthetic route

1082041-53-9Upstream product

1082041-53-9Downstream Products