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CAS No.: | 1082041-53-9 |
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Name: | 6-Iodo-3-methyl-1H-indazole |
Molecular Structure: | |
Formula: | C8H7IN2 |
Molecular Weight: | 258.05900 |
Synonyms: | 6-Iodo-3-methyl-1H-indazole;1H-INDAZOLE,6-IODO-3-METHYL;INDAZOLE,6-IODO-3-METHYL; |
PSA: | 28.68000 |
LogP: | 2.47590 |
3,4-dihydro-2H-pyran
C8H7IN2
Conditions | Yield |
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With methanesulfonic acid In tetrahydrofuran at 80℃; for 8h; Inert atmosphere; | 81% |
C8H7IN2
methyl 2,2,2-trichloroacetimidate
6-iodo-2,3-dimethyl-2H-indazole
Conditions | Yield |
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Stage #1: C8H7IN2 With trifluorormethanesulfonic acid In dichloromethane at 25 - 35℃; Inert atmosphere; Stage #2: methyl 2,2,2-trichloroacetimidate In dichloromethane at 20℃; Inert atmosphere; regioselective reaction; |
C8H7IN2
Conditions | Yield |
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Multi-step reaction with 3 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere 3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere View Scheme |
C8H7IN2
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere 3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C 5: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme |
C8H7IN2
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere View Scheme |
C8H7IN2
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: methanesulfonic acid / tetrahydrofuran / 8 h / 80 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere 3: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme |