108221-64-3Relevant academic research and scientific papers
Methods of inhibiting the advanced glycosylation of proteins using tetramic and tetronic acids and compositions therefor
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, (2008/06/13)
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted or unsubstituted tetramic and tetronic acids capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
Ultrasound-Promoted Synthesis of Fluorinated β-Keto-γ-butyrolactones
Kitazume, Tomoya
, p. 855 - 857 (2007/10/02)
A number of β-keto-γ-butyrolactones and tetronic acids bearing a fluorine atom or a trifluoromethyl group were prepared by the ultrasound-promoted, Reformatsky-type reaction of O-trimethylsilylated cyanohydrins and ethyl α-fluoro(or α-trifluoromethyl)bromoacetate.
