66985-48-6

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 33646-40-1 4-methoxymandelonitrile 
• 151-50-8 potassium cyanide 
• 123-11-5 4-methoxy-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 177755-45-2 2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 75748-09-3 (4-methoxybenzoyl)trimethylsilane 
• 579-74-8 2-Methoxyacetophenone 
• 13329-40-3 4-Iodoacetophenone 
• 2142-69-0 2-bromophenyl methyl ketone 
• 5407-98-7 1-cyclobutyl-1-phenyl-methanone 
• 108-94-1 cyclohexanone 
• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 

Downstream Products

• 50802-67-0 threo-2-amino-1-(4-methoxyphenyl)propan-1-ol 
• 50802-67-0 erythro-2-amino-1-(4-methoxyphenyl)propan-1-ol 
• 120390-77-4 (R)-(-)-1-hydroxy-1-(4-methoxyphenyl)propan-2-one 
• 73183-29-6 3-(4-methoxybenzoyl)cyclohexanone 
• 73183-14-9 1-(4-methoxyphenyl)-2,4-dimethyl-2-((trimethylsilyl)oxy)pent-3-en-1-one 
• 73183-18-3 2-(4-Methoxy-phenyl)-3,3-dimethyl-5-oxo-2-trimethylsilanyloxy-hexanenitrile 
• 108221-64-3 3-fluoro-5-(4-methoxyphenyl)-2,4(3H,5H)-furandione 
• 87712-84-3 (R,R)-(+)-α-<(1-phenylethyl)amino>-α-(4-methoxyphenyl)acetonitrile hydrochloride 
• 87712-86-5 (S,S)-(-)-α-<(1-phenylethyl)amino>-α-(4-methoxyphenyl)acetonitrile hydrochloride 
• 96824-36-1 (S)-(4-Methoxy-phenyl)-((R)-1-phenyl-ethylamino)-acetonitrile; hydrochloride 
• 97847-92-2 2,4,6-Cycloheptatrien-1-yl(4-methoxyphenyl)(trimethylsiloxy)acetonitril 
• 85841-79-8 erythro-2-amino-1-(4-methoxyphenyl)-2-phenylethanol 
• 85841-79-8 threo-2-amino-1-(4-methoxyphenyl)-2-phenylethanol 
• 138566-56-0 4-(4-benzyloxy-3,5-dimethoxyphenyl)-1-(p-methoxyphenyl)-3-methylbutan-1-one 

Relevant academic research and scientific papers

Robust molecular bowl-based metal-organic frameworks with open metal sites: Size modulation to increase the catalytic activity

Herein, two stable lead(II) molecular-bowl-based metal-organic frameworks and their micro- and nanosized forms with open metal sites were presented. These materials could act as Lewis acid catalysts to cyanosilylation reaction. Moreover, the catalytic per

A Polyhedral Metal-Organic Framework Based on Supramolecular Building Blocks: Catalysis and Luminescent Sensing of Solvent Molecules

A multifunctional polyhedral metal-organic framework with a pcu network topology based on supramolecular building blocks can be constructed by the reaction of Eu(NO3)3 and pyridine-3,5-dicarboxylic acid (H2PDC). The basic

Three scandium compounds with unsaturated coordinative metal sites - Structures and catalysis

Two scandium coordination polymers, a 2D supermolecule structure {[Sc(OH)(L1)2(H2O)]}n (1) (HL1 = isonicotinic acid), a 1D infinite chain structure {[Sc3(L2)4(H2

Novel isopolyoxotungstate [H2W11O38] 8- based metal organic framework: As lewis acid catalyst for cyanosilylation of aromatic aldehydes

A novel polyoxometalate-based metal organic framework (POMOF) constructed from isolated isopolyoxotungstate [H2W11O 38]8- cluster, {[Cu2(bpy)(H2O) 5.5]2[H2W11O38] ·3H2O·0.5CH3CN} (1, where bpy = 4,4′-bpydine), has been synthesized under solvothermal conditions and charaterized by elemental analysis, infrared spectroscopy, and single-crystal X-ray diffraction. In 1, {W11} clusters are alternately linked by two [Cu(2)(H2O)1.5(Ot)3(N)] 2+ cations in an unexpected end-to-end fashion leading to a one-dimensional (1D) chain. Adjacent 1D chains are linked through Cu(1)-bpy-Cu(2) in an opposite direction to form a two-dimensional (2D) wavelike sheet along the ab plane. These 2D sheets are further stacked in a parallel fashion giving rise to the 1D channels with copper(II) cations aligned in the channels. The resulting POMOF acted as a Lewis acid catalyst through a heterogeneous manner to prompt cyanosilylation with excellent efficiency.

Cyanosilylation of carbonyl compounds catalyzed by half-sandwich (η6-p-cymene) Ruthenium(II) complexes bearing heterocyclic hydrazone derivatives

A new class of half-sandwich (?6-p-cymene) ruthenium(II) complexes supported by heterocyclic hydrazone derivatives of general formula [Ru(?6-p-cymene)(Cl)(L)] where L represents N’-((1H-pyrrol-2-yl)methylene)furan-2-carbohydrazide (L

Conjugated Bis-Guanidines (CBGs) as β-Diketimine Analogues: Synthesis, Characterization of CBGs/Their Lithium Salts and CBG Li Catalyzed Addition of B?H and TMSCN to Carbonyls

Herein, we report a range of conjugated bis-guanidines (CBGs) L [L={(ArHN)(ArHN)C=N?C=(NAr)(NHAr)}; Ar=2, 6-Me2 - C6H3, (1), 2, 4, 6-Me3?C6H2, (2), 2, 6-Et2?C6H3

Role of metal center and coordination environment in M-(Z)-N-((E)-pyridin-2-ylmethylene)isonicotinohydrazonate (M = LaIII, ZnII, CdII or HgII) catalyzed cyanosilylation of aldehydes

A series of known metal complexes, [LaL2(NO3)(H2O)2]·5H2O (1), [Zn(μ-L)(NO3)(H2O)]n (2), {[Cd2(μ-HL)(μ-L)(NO3)3(H2O)]·Hsub

Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis

Cyanosilylation of carbonyl compounds provides protected cyanohydrins, which can be converted into many kinds of compounds such as amino alcohols, amides, esters, and carboxylic acids. In particular, the use of trimethylsilyl cyanide as the sole carbon source can avoid the need for more toxic inorganic cyanides. In this paper, we describe an electrochemically initiated cyanosilylation of carbonyl compounds and its application to a microflow reactor. Furthermore, to identify suitable reaction conditions, which reflect considerations beyond simply a high yield, we demonstrate machine learning-assisted optimization. Machine learning can be used to adjust the current and flow rate at the same time and identify the conditions needed to achieve the best productivity.

Zirconium-based MOF catalyst with double active sites and preparation method and application thereof

The invention discloses a zirconium-based MOF catalyst loaded with double active sites as well as a preparation method and an application of the zirconium-based MOF catalyst. The method comprises thefollowing steps: adding zirconium salt and an organic ligand into an organic solvent, taking organic acid as a regulator, and carrying out self-assembly reaction to obtain a metal organic framework; adding salicylaldehyde for aldehyde amine condensation to obtain chelating coordination sites, adding palladium salt, and performing coordination through an impregnation method; reducing the obtained MOF in hydrogen to obtain an MOF loaded with Pd nanoparticles; reacting MOF and zinc salt in an organic solvent, and obtaining the catalyst. The Pd-Zn-coated UiO-68-NH2-CH3 catalyst synthesized by thepreparation method disclosed by the invention has efficient catalytic activity in a tandem alcohol oxidation/aldehyde cyanosilylation reaction. According to the catalyst, a metal organic framework UiO-68-NH2-CH3 is constructed, Pd nanoparticles and Zn are loaded by taking the metal organic framework UiO-68-NH2-CH3 as a carrier, the loading capacity of the Pd nanoparticles is 4-8wt%, and the loading capacity of the Zn is 3-5wt%.

H-Bonded and metal(ii)-organic architectures assembled from an unexplored aromatic tricarboxylic acid: structural variety and functional properties

This study reports the application of an aromatic tricarboxylic acid, 2,5-di(4-carboxylphenyl)nicotinic acid (H3dcna) as a versatile and unexplored organic building block for assembling a new series of metal(ii) (M = Co, Ni, Zn, Fe, and Mn) complexes and coordination polymers, namely [M(Hdcna)(phen)2(H2O)]·H2O (M = Co (1), Ni (2)), [Zn(μ-Hdcna)(phen)]n(3), [Co(μ-Hdcna)(bipy)(H2O)2]n·nH2O (4), [Zn2(μ-Hdcna)2(bipy)2(H2O)4]·6H2O (5), [Zn(μ3-Hdcna)(H2biim)]n(6), [Ni2(Hdcna)2(μ-bpb)(bpb)2(H2O)4] (7), [Fe(μ4-Hdcna)(μ-H2O)]n·nH2O (8), and [Mn3(μ5-dcna)2(bipy)2(H2O)2]n·2nH2O (9). Such a diversity of products was hydrothermally prepared from the corresponding metal(ii) salts, H3dcna as a principal multifunctional ligand, and N-donor mediators of crystallization (1,10-phenanthroline, phen; 2,2'-bipyridine, bipy; 2,2'-biimidazole, H2biim; or 1,4-bis(pyrid-4-yl)benzene, bpb). The obtained products1-9were fully characterized by standard methods (elemental analysis, FTIR, TGA, PXRD) and the structures were established by single-crystal X-ray diffraction. These vary from the discrete monomers (1,2) and dimers (5,7) to the 1D (3,4,6) and 2D (8,9) coordination polymers (CPs). Structural and topological characteristics of hydrogen-bonded or metal-organic architectures in1-9were highlighted, revealing that their structural multiplicity depends on the type of metal(ii) source and crystallization mediator. Thermal stability as well as luminescent, magnetic, or catalytic properties were explored for selected compounds. In particular, the zinc(ii) derivatives3,5, and6were applied as efficient heterogeneous catalysts for the cyanosilylation of aldehydes with trimethylsilyl cyanide at room temperature. The catalytic reactions were optimized by tuning the different reaction parameters (solvent composition, time, catalyst loading) and the substrate scope was also explored. Compound5revealed superior catalytic activity leading to up to 75% product yields, while maintaining its original performance upon recycling for at least four reaction cycles. Finally, the obtained herein products represent the unique examples of coordination compounds derived from H3dcna, thus opening up the use of this multifunctional tricarboxylic acid for generating complexes and coordination polymers with interesting structures and functional properties.