1910-90-3

Usage

Uses

Used in Pharmaceutical Industry:
6-bromo-1,4-dihydro-quinoxaline-2,3-dione is used as a pharmaceutical agent for its antimicrobial and antifungal properties, making it a potential candidate for the development of new drugs to combat resistant infections.
Used in Organic Synthesis:
6-bromo-1,4-dihydro-quinoxaline-2,3-dione serves as a building block in organic synthesis, contributing to the creation of a variety of other organic compounds, thus expanding the scope of chemical research and development.
Used in Medicinal Chemistry Research:
As a compound with unique structural features, 6-bromo-1,4-dihydro-quinoxaline-2,3-dione is utilized in medicinal chemistry research to explore its potential interactions with biological targets and its role in the design of novel therapeutic agents.

InChI:InChI=1/C8H5BrN2O2/c9-4-1-2-5-6(3-4)11-8(13)7(12)10-5/h1-3H,(H,10,12)(H,11,13)

Upstream product

• 144-62-7 oxalic acid 
• 1575-37-7 4-Bromo-benzene-1,2-diamine 

Downstream Products

• 115581-82-3 6-Bromo-2,3-dihydroxy-7-nitroquinoxaline 
• 108229-82-9 7-bromo-2,3-dichloroquinoxaline 

Relevant academic research and scientific papers

Novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and preparation and application thereof

The invention provides a novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and a preparation method and application thereof, and belongs to the field of chemical medicines. The derivative is a compound as shown in a formula I, or a salt thereof, or a stereoisomer thereof. The compound is low in toxicity or basically non-toxic to normal cells, has an obvious inhibition effect to tumor cell lines, particularly has good lipid toxicity selectivity to tumor cells such as liver cancer, lung cancer and the like in vivo, and has an obvious inhibition effect; meanwhile, the compound can effectively activate SREBP1 and PPAR gamma, inhibit lipid transport MTTP, cause lipid aggregation in tumor cells and cause lipid toxicity of the tumor cells. The compound can be used for treating liver cancer, lung cancer and the like in a molecular targeting manner, is low in toxicity or even non-toxic, and has a good application prospect.

A One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives 3a–n. The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamine and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines have been obtained in good to excellent overall yields. Eight known compounds 3a–3h were characterized by IR, 1H-NMR, and mass spectroscopies. Compounds 3i–3n without spectroscopic data were characterized by IR, 1H-NMR, 13C-NMR, and mass spectroscopies.