1082307-72-9Relevant academic research and scientific papers
Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs
Mochona, Bereket,Jackson, Timothy,McCauley, DeCoria,Mazzio, Elizabeth,Redda, Kinfe K.
, p. 1871 - 1877 (2016/11/23)
Azomethine-linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4-oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR,1H-NMR,13C-NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer cell lines (MDA-AB-231, BT-474, and Ishikawa cells) revealed that the pyrrole–benzimidazole hybrids are more potent than the pyrazolone and 1,3,4-oxadiazole hybrids in all cell lines. Compound 9 displayed promising cytotoxicity against BT-474 cell line with IC50values, 7.7 μM.
Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole
Sparke, Amanda E.,Fisher, Christopher M.,Mewis, Ryan E.,Archibald, Stephen J.
body text, p. 4723 - 4726 (2010/09/20)
The synthesis of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole, which undergoes a nucleophilic substitution with pyridine in the absence of additional base, is reported. The key steps are the reaction of 1,2-phenylenediamine to give exclusively the mono-
