1082429-76-2

Upstream product

• 60467-61-0 2-amino-3-(4-fluorophenyl)-1,8-naphthyridine 
• 459-22-3 4-fluorophenylacetonitrile 
• 7521-41-7 2-Aminonicotinaldehyde 

Downstream Products

• 1153668-78-0 2-hydrazino-3-(4-fluorophenyl)-1,8-naphthyridine 
• 1345691-28-2 C₂₁H₁₅FN₄ 
• 1345691-29-3 C₂₂H₁₇FN₄ 
• 1345691-30-6 C₂₂H₁₇FN₄O 
• 1345691-31-7 C₂₁H₁₄ClFN₄ 
• 1345691-32-8 C₂₁H₁₄ClFN₄ 
• 1345691-33-9 C₂₁H₁₄FN₅O₂ 
• 1345691-34-0 C₂₁H₁₄FN₅O₂ 
• 1345691-35-1 C₂₃H₁₉FN₄O₂ 
• 1345691-36-2 C₂₁H₁₃FN₄ 
• 1345691-37-3 C₂₂H₁₅FN₄ 
• 1345691-38-4 C₂₂H₁₅FN₄O 
• 1345691-39-5 C₂₁H₁₂ClFN₄ 
• 1345691-40-8 C₂₁H₁₂ClFN₄ 

Relevant academic research and scientific papers

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.

Green synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines using PhI(OAc)2-Al2O3 under microwave irradiation

Alumina-supported iodobenzene diacetate [PhI(OAc)2-Al 2O3] is a highly efficient reagent for the oxidative cyclization of N-arylidene-N′-[3-(4-fluorophenyl)-[1,8]naphthyridin-2-yl]- hy-drazines 7 to 1-aryl-4-[4-fluoro phenyl]-1,2,4-triazolo[4,3-a][1,8] naphthyridines 8 in solvent-free conditions under microwave irradiation. The products are obtained in good yields and excellent purities. The structural assignments of compounds 3-8 were based on their spectral (IR, 1H NMR and MS) and analytical data.