1082525-32-3Relevant academic research and scientific papers
PYRROLIDINYL DERIVATIVES AND USES THEREOF
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, (2009/10/22)
The invention relates to 3,3 disubstituted pyrrole derivatives useful for treatment of diseases associated with monoamine reuptake inhibitors.Also provided pharmaceutical compositions, methods of using, and methods of preparing the compounds.
Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors
Bannwart, Linda M.,Carter, David S.,Cai, Hai-Ying,Choy, Jason C.,Greenhouse, Robert,Jaime-Figueroa, Saul,Iyer, Pravin S.,Lin, Clara J.,Lee, Eun Kyung,Lucas, Matthew C.,Lynch, Stephen M.,Madera, Ann Marie,Moore, Amy,Ozboya, Kerem,Raptova, Lubica,Roetz, Ralf,Schoenfeld, Ryan C.,Stein, Karin Ann,Steiner, Sandra,Villa, Marzia,Weikert, Robert J.,Zhai, Yansheng
scheme or table, p. 6062 - 6066 (2009/06/30)
A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro microsomal stability and in vitro permeability, and low drug-drug interaction potential are described. One example showed in vivo anti-depressant-like effects in the mouse tail suspension assay with a minimum effective dose of 30 mg/kg ip.
