108263-70-3Relevant academic research and scientific papers
One-pot synthesis of diverse: N, N ′-disubstituted guanidines from N -chlorophthalimide, isocyanides and amines via N -phthaloyl-guanidines
Demjén, András,Angyal, Anikó,W?lfling, János,Puskás, László G.,Kanizsai, Iván
, p. 2143 - 2149 (2018)
A sequential one-pot approach towards N,N′-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This protocol also features wide substrate scope and mild conditions.
