108267-19-2

Upstream product

• 108186-61-4 <(1S,2S,3R)-3-hydroxy-2-nitrocyclohexyl>-acetat 
• 38150-01-5 (1α,2β,3α)-2-nitro-1,3-cyclohexanediol 
• 51269-14-8 (1R,2r,3S)-3-acetoxy-2-nitrocyclohexyl acetate 
• 111-30-8 Glutaraldehyde 

Downstream Products

• 129967-78-8 (2S,1'S,2'S)-2-(2'-nitro-3-cyclohexenyl)pentane-3-one 
• 129967-87-9 (S)-2-((S)-2-Nitro-cyclohex-2-enyl)-pentan-3-one 
• 129967-89-1 (2S,1'S)-2-(2'-aci-nitro-3'-cyclohexenyl)pentane-3-one 
• 129967-88-0 (2R,1'S)-2-(2'-nitro-2-cyclohexenyl)pentane-3-one 
• 129967-76-6 (S)-2-(2'-nitrocyclohexenyl)-1-phenylethan-1-one 
• 108186-63-6 (S)-2-nitro-2-cyclohexenol 
• 114455-01-5 <2,3-dibromo-2-nitrocyclohexyl>-acetat 

Relevant academic research and scientific papers

Enantioselective Saponification of Diacetates of 2-Nitro-1,3-propanediols by Pig-Liver Esterase and Preparation of Enantiomerically Pure Derivatives of 2-Nitro-allylic Alcohols (Chiral Multiple-Coupling Reagents)

The reproducible enantioselective saponification of open-chain and cyclic diacetates of meso-2-nitro-1,3-propanediols (see 4b-13b) with pig-liver esterase (PLE) gives monoacetates (see 4c-13c) of >95percent enantiomeric excess.The Re enantiotopic acetate group appears to be saponified preferentially, as proved by the X-ray crystal structure analysis of three camphanoates 4d, 6d, and 7d.Elimination of H2O or AcOH from the hydroxy acetates thus available gives derivatives of nitro-allylic alcohols (see 20-24, 27, and 29) which are subjected to diastereoselective Michael additions or SN2' substitutions.