108267-40-9Relevant academic research and scientific papers
An improved water-soluble/stereospecific biotransformation of aporphine alkaloids in Stephania epigaea to 4R-hydroxyaporphine alkaloids by Clonostachys rogersoniana
Cai, Le,Dong, Jian-Wei,Zhao, Li-Xing,Zhou, Hao,Xing, Yun,Li, Ying,Li, Zhen-Jie,Duan, Wei-He,Li, Xue-Jiao,Ding, Zhong-Tao
, p. 933 - 940 (2016)
Aporphine alkaloids were transformed into the corresponding stereospecific 4R-hydroxyaporphine alkaloids through the solid-state fermentation of Stephania epigaea with Clonostachys rogersoniana. This process was validated by both solid- and liquid-state fermentations with aporphine alkaloids as substrates. Cytochrome P450 enzymes were confirmed to participate in the catalysis of this biotransformation. 4R-Hydroxyaporphine alkaloids exhibit the same levels of acetylcholinesterase (AChE) inhibitory and cytotoxic activities as aporphine alkaloids and are considerably more water soluble than aporphine alkaloids, indicating their potential as water-soluble AChE inhibitors and antitumor agents. This paper suggests that C. rogersoniana fermentation can facilitate a novel biotransformation of aporphine alkaloids in S. epigaea to 4R-hydroxyaporphine alkaloids.
THE SYNTHESIS OF d1-STEPORPHINE, 4-HYDROXYAPORPHINE TYPE ALKALOIDS.
Kunitomo, Jun-ichi,Oshikata, Megumi,Suwa, Kiyoko,Nakayama, Kayoko,Murakami, Yoshiko
, p. 45 - 48 (2007/10/02)
A 4-hydroxyaporphine type alkaloid, steporphine (1), has been stereospecifically synthesized for the first time.
