1082746-80-2Relevant academic research and scientific papers
Structural study of diarylazoles related to Rimonabant
Alkorta, Ibon,Alvarado, Mario,Elguero, José,García-Granda, Santiago,Goya, Pilar,Torre-Fernández, Laura,Menéndez-Taboada, Laura
experimental part, p. 82 - 89 (2009/06/27)
The structures of three diarylazoles (two pyrazoles and one 1,2,4-triazole) related to Rimonabant have been determined by X-ray crystallography. The conformation of both aryl groups in the new structures is discussed with regard to other related compounds
Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents
Alvarado, Mario,Goya, Pilar,Macias-Gonzalez, Manuel,Pavon, Francisco Javier,Serrano, Antonia,Jagerovic, Nadine,Elguero, Jose,Gutierrez-Rodriguez, Angel,Garcia-Granda, Santiago,Suardiaz, Margarita,Rodriguez de Fonseca, Fernando
experimental part, p. 10098 - 10105 (2009/04/06)
Searching for new antiobesity agents, a new series of fatty acid amide derivatives of 1,5-diarylpyrazole have been synthesized as dual peroxisome proliferator activated receptor alpha (PPARα)/cannabinoid receptor ligands. The compounds have been evaluated in vivo and in vitro as PPARα activators and as cannabinoids in two tests of the mouse tetrad. In vivo, food intake studies have been performed with all the compounds. No significant cannabinoid activity has been found but some compounds behaved as potent PPARα activators. Several compounds showed anorexigenic properties reducing food intake in rats.
