108282-52-6

Upstream product

• 2138-34-3 1-(4-bromo-phenyl)-3-dimethylamino-propan-1-one 
• 74-88-4 methyl iodide 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 22731-70-0 1-(4-bromophenyl)prop-2-en-1-one 
• 579490-11-2 3-[4-(2-benzhydryloxy-ethyl)-piperazin-1-yl]-1-(4-bromo-phenyl)-propan-1-one 
• 579490-13-4 3-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-yl)-1-(4-bromo-phenyl)-propan-1-one 
• 108257-98-3 4-formyl-1-(4-bromophenyl)hexanone 
• 108257-97-2 1-[6-(4-Bromo-phenyl)-3-propyl-3,4-dihydro-2H-pyran-2-yl]-piperidine 
• 108257-96-1 1-[6-(4-Bromo-phenyl)-3-ethyl-3,4-dihydro-2H-pyran-2-yl]-piperidine 
• 99217-20-6 2-(4-bromophenyl)-5-ethylpyridine 
• 99217-21-7 2-(4-bromophenyl)-5-propylpyridine 

Relevant academic research and scientific papers

Further exploration of 1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}piperazine (GBR 12909): Role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter

A series of N-aromatic, N-heteroaromatic, and oxygenated N-phenylpropyl derivatives of 1-(2-benzhydryloxyethyl)-piperazine and 1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}piperazine, analogues of GBR 12909 (1a) and 12935 (1b), was synthesized and examined for their dopamine (DAT) and serotonin (SERT) transporter binding properties. One of these compounds, racemic 3-[4-(2-benzhydryloxyethyl)piperazin-1-yl]-1-(3-fluorophenyl)-propan-1-ol (33), had DAT affinity as good as, or better than, GBR 12909 and 12935, and was more selective for DAT over SERT than the GBR compounds. Both trans- (43) and cis- (47) (±)-2-(4-{2-[bis-(4-fluorophenyl)-methoxy]ethyl}piperazin-1- ylmethyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol had relatively good SERT selectivity and, as well, showed high affinity for SERT.

5-ALKYL-2-(4-BROMOPHENYL)PYRIDINES

The cyclization of 1-acryloyl-4-bromobenzene with trans-1-N-piperidino-1-alkenes gave 3-alkyl-6-(4-bromophenyl)-3,4-dihydro-2-N-piperidino-2H-pyrans.These products were converted by the action of hydroxylamine to 5-alkyl-2-(4-bromophenyl)pyridines.