1082826-41-2Relevant academic research and scientific papers
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor
Chambers, Laura J.,Stevens, Alexander J.,Moses, Andrew P.,Michel, Anton D.,Walter, Daryl S.,Davies, David J.,Livermore, David G.,Fonfria, Elena,Demont, Emmanuel H.,Vimal, Mythily,Theobald, Pam J.,Beswick, Paul J.,Gleave, Robert J.,Roman, Shilina A.,Senger, Stefan
scheme or table, p. 3161 - 3164 (2010/09/10)
High-throughput screening identified compound 1 as a potent P2X7 receptor antagonist suitable for lead optimisation. Structure-activity relationships (SAR) of a series of (1H-pyrazol-4-yl)acetamides were investigated and compound 32 was identif
PYRAZOLE DERIVATIVES AS P2X7 MODULATORS
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, (2009/01/20)
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The pyrazole derivatives of formula (I) or salts thereof modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2
