1082852-48-9Relevant academic research and scientific papers
Fe(III)-Catalyzed, Cyclizative Coupling between 2-Alkynylbenzoates and Carbinols: Rapid Generation of Polycyclic Isocoumarins and Phthalides and Mechanistic Study
Gandhi, Soniya,Baire, Beeraiah
, p. 2651 - 2657 (2020)
FeCl3 catalyzed, highly regioselective cyclizative coupling of internal alkynes with alcohols has been reported for the rapid synthesis of structurally divergent, complex isocoumarins and phthalides respectively in intermolecular and intramolecular fashion. This strategy exhibited very high substrate scope and efficiency and proceeds through the simultaneous formation of C?O and C?C bonds. Observations from a series of control experiments supported a) the mechanism as Lewis acid catalyzed dual activation of ester and alcohol, b) the role of carbocation for the enhanced rates of cyclization, i. e., activation of alkyne by carbocation, and c) no role of HCl in the reported cascade process. (Figure presented.).
Bismuth-catalyzed intramolecular carbo-oxycarbonylation of 3-alkynyl esters
Komeyama, Kimihiro,Takahashi, Keita,Takaki, Ken
supporting information; experimental part, p. 5119 - 5122 (2009/05/30)
(Chemical Equation Presented) Borderline metal complexes, especially Bi(OTf)3, efficiently catalyze the carbo-oxycarbonylation of alkynyl esters to form multisubstituted lactones in moderate to high yields.
