108288-16-0

Usage

Uses

Used in Pharmaceutical Industry:
BENZOIC ACID,2-AMINO-4-CHLORO-5-FLUOROis used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a valuable building block for the development of new drugs with specific therapeutic properties.
Used in Anticancer Applications:
BENZOIC ACID,2-AMINO-4-CHLORO-5-FLUOROis used as a precursor for the synthesis of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents. These agents work by inhibiting tubulin polymerization, which is a crucial process for cell division and proliferation. By disrupting this process, 2-styrylquinazolin-4(3H)-ones can effectively combat cancer cells and potentially lead to the development of novel cancer treatments.

Upstream product

• 108288-15-9 N-(3-Chloro-4-fluorophenyl)-2-(hydroxyimino)acetamide 
• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 108288-17-1 4-Chloro-5-fluoro-2-<(2-nitroethylidene)amino>benzoic acid 
• 141328-40-7 2-[ N-(4-allyloxy-3,5-dimethoxybenzyl)-amino]-4-chloro-5-fluorobenzoic acid 

Relevant academic research and scientific papers

FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF

AbstractNovel compounds of the following formula (I) and pharmacologically acceptable salt and esters thereof can modulate LXR function and as a result show excellent anti-arteriosclerotic and anti-inflammatory activity:wherein:A represents aryl or heteroaryl;R1, R2 and R3 are the same or different and each represents hydrogen, hydroxyl, nitro, cyano, amino, halogen, carboxy, carbamoyl, mercapto, alkyl, haloalkyl, alkylcarbonyloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonylamino, N-(alkylcarbonyl)-N-(alkyl)amino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, alkylsulfonylamino, N-(alkylsulfonyl)-N-(alkyl)amino, haloalkylsulfonylamino, N-(haloalkylsulfonyl)-N-(alkyl)amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, or R1 and R2 together are alkylenedioxy;R4 and R5 are the same or different and each represents hydrogen, hydroxyl, amino, halogen, mercapto, alkyl, haloalkyl, alkoxy, alkoxycarbonyl or alkylthio;X represents hydrogen, hydroxyl, halogen, alkoxy or haloalkoxy; andY represents an optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, cycloalkylalkyl, heterocyclylalkyl or aralkyl group.