1083-11-0

Basic information

• Product Name: 4-(2 5-DIMETHOXYPHENYL)BUTYRIC ACID 97
• Synonyms: 4-(2 5-DIMETHOXYPHENYL)BUTYRIC ACID 97;4-(2,5-dimethoxyphenyl)butanoic acid;4-(2,5-Dimethoxyphenyl)butyric acid,4-(2,5-Dimethoxyphenyl)butanoic acid
• CAS NO: 1083-11-0
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.25
• Product Categories: Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 1083-11-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 67-71 °C(lit.)
• Boiling Point: 368.7°Cat760mmHg
• Flash Point: 139.4°C
• Appearance: /
• Density: 1.133g/cm³
• Vapor Pressure: 4.37E-06mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 4-(2 5-DIMETHOXYPHENYL)BUTYRIC ACID 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2 5-DIMETHOXYPHENYL)BUTYRIC ACID 97(1083-11-0)
• EPA Substance Registry System: 4-(2 5-DIMETHOXYPHENYL)BUTYRIC ACID 97(1083-11-0)

Safety Data

• Hazard Codes: Xi
• Statements: 38-36
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1083-11-0(Hazardous Substances Data)

Usage

General Description

4-(2 5-DIMETHOXYPHENYL)BUTYRIC ACID 97 is a chemical compound with the molecular formula C13H18O5. It is a derivative of butyric acid and contains a phenyl group with two methoxy substituents at the 2 and 5 positions. This chemical is often used in the pharmaceutical and research industries as a building block for the synthesis of various compounds. It has a purity of 97%, making it suitable for use in high-quality applications. 4-(2 5-DIMETHOXYPHENYL)BUTYRIC ACID 97 is known for its mild odor and is soluble in organic solvents. It is important to handle this chemical with care and use appropriate safety precautions when working with it.

InChI:InChI=1/C12H16O4/c1-15-10-6-7-11(16-2)9(8-10)4-3-5-12(13)14/h6-8H,3-5H2,1-2H3,(H,13,14)

Upstream product

• 150-78-7 1,4-dimethoxybezene 
• 83655-42-9 4-(2,5-dimethoxyphenyl)-3-butenoic acid 
• 108-30-5 succinic acid anhydride 
• 1084-74-8 3-(2,5-dimethoxybenzoyl)propionic acid 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 5115-18-4 (+/-)-γ-Rhodomycinon 
• 84944-55-8 2-ethyl-4(4'-bromo-2'5'-dimethoxyphenyl) butyric acid 
• 1121703-29-4 C₂₉H₃₄N₂O₅ 
• 1121703-31-8 C₂₂H₂₈N₂O₅ 
• 1326317-20-7 methyl 2-(4-(2,5-dimethoxyphenyl)butanoyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 1326317-19-4 methyl 2-(4-(2,5-dimethoxyphenyl)butanoyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 1326317-05-8 1-(5,6-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)-4-(2,5-dihydroxyyphenyl)butan-1-one 
• 70526-14-6 ethyl 4-(2,5-dimethoxyphenyl)butyrate 
• 73846-08-9 4-(2,5-Dimethoxy-phenyl)-2-formyl-butyric acid ethyl ester 
• 101788-59-4 5,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one-(2,4-dinitro-phenylhydrazone) 
• 75251-98-8 2-acetyl-5,8-dimethoxy-3,4-dihydronaphthalene 
• 121364-90-7 2-{2,5-Dimethoxy-4-[3-(2,2,2-trichloro-ethoxycarbonyl)-propyl]-benzoyl}-3-methoxy-benzoic acid methyl ester 
• 121364-87-2 2,2,2-trichloroethyl 4-<2,5-dimethoxyphenyl>butyrate 
• 99316-53-7 1-benzyloxy-5,8-dimethoxy-naphthalene 

Relevant articles and documents

A Radical-Based Synthesis of Lingzhiol

The polycyclic natural product lingzhiol [(±)-1] was synthesized from dimethoxytetralone 8 via cyclization of an intermediate benzylic radical, generated from spiroepoxide 14, onto an alkynyl substituent generating tetracyclic compound 13 with an exocyclic double bond. After oxidative cleavage of the double bond of 13 and reduction of the keto function of 23, the correct diastereomer, 12-syn, was converted to lingzhiol (1) via known steps. In a similar manner, lingzhiol analogue 39 was synthesized from 5-methoxy-1-tetralone (27).

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.

Direct synthesis of γ-butyrolactones via γ-phenyl substituted butyric acids mediated benzyl radical cyclization

Synthesis of several γ-butyrolactones with aromatic substitution at carbon 5 from comparative γ-aryl acids with 25-85% yield are covered. The straight oxidation in the presence of peroxydisulphate-copper(II)chloride system in aqueous medium was applied. The reaction is highly regioselective and leads exclusively to γ-butyrolactone, through stable benzylic radical intermediate.