1083-41-6

Basic information

• Product Name: BUTYL GALLATE
• Synonyms: GALLIC ACID N-BUTYL ESTER;GALLIC ACID BUTYL ESTER;BUTYL 3,4,5-TRIHYDROXYBENZOATE;BUTYL GALLATE;N-BUTYL GALLATE;N-BUTYL-3,4,5-TRIHYDROXYBENZOATE;3,4,5-trihydroxy-benzoicacibutylester;butylesterkyselinygallove
• CAS NO: 1083-41-6
• Molecular Formula: C₁₁H₁₄O₅
• Molecular Weight: 226.23
• EINECS: 214-107-7
• Product Categories: Pharmaceutical Intermediates;Aromatic Esters
• Mol File: 1083-41-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 144°C
• Boiling Point: 452.7 °C at 760 mmHg
• Flash Point: 179 °C
• Appearance: /
• Density: 1.314 g/cm³
• Vapor Pressure: 8.22E-09mmHg at 25°C
• Refractive Index: 1.583
• PKA: 7.93±0.25(Predicted)
• CAS DataBase Reference: BUTYL GALLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BUTYL GALLATE(1083-41-6)
• EPA Substance Registry System: BUTYL GALLATE(1083-41-6)

Safety Data

• RTECS: LW7600000
• Hazardous Substances Data: 1083-41-6(Hazardous Substances Data)

Usage

General Description

Butyl gallate, also known as tetrabutyl hydroxyhydrocinnamate, is a chemical compound that is used as an antioxidant and preservative in various products, including food, cosmetics, and pharmaceuticals. It is a member of the gallate family, which are esters of gallic acid, and is derived from natural sources such as plants and fruits. Butyl gallate is effective in preventing the oxidation of fats and oils, which can lead to rancidity and spoilage in food products. It is also used to preserve the quality and stability of cosmetics and pharmaceuticals by inhibiting the degradation of ingredients. However, there are some concerns about potential health risks associated with butyl gallate, and its use in certain applications is regulated by authorities to ensure safe levels of exposure.

InChI:InChI=1/C11H14O5/c1-2-3-4-16-11(15)7-5-8(12)10(14)9(13)6-7/h5-6,12-14H,2-4H2,1H3

Upstream product

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• 1329454-74-1 butyl 3-O-(β-D-glucopyranosyl)-4,5-dihydroxybenzoate 
• 1329454-92-3 butyl 3-O-(methyl-2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)-4,5-dihydroxybenzoate 
• 1329454-63-8 butyl 3-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside)-4,5-dihydroxybenzoate 

Related news

Encapsulation and solubilization of the antioxidants gallic acid and ethyl, propyl and BUTYL GALLATE (cas 1083-41-6) with β-cyclodextrin08/12/2019

We investigated the formation of inclusion complexes of the antioxidants (AOs) gallic acid, GA, and its hydrophobic derivatives ethyl (EG), propyl (PG) and butyl (BG) gallate with β-cyclodextrin (β-CD) by employing the UV spectral shifts method and, for the sake of comparisons, a modified phas...detailed

Relevant articles and documents

Microwave-assisted esterification of gallic acid

An efficient synthesis of alkyl gallates under microwave irradiation was described. The reaction took place in 6-10 mins, which was much shorter than the traditional synthetic methods, with almost quantitative yields.

A preparation method of electronic grade gallic octyl ester

The present invention provides a kind of electronic grade gallic octyl ester of preparation method, which belongs to the technical field of organic synthesis. The gallic acid dissolved in alcohol, then drop adds the chlorination [...], then adding aromatic hydrocarbon solvent, a catalytic amount of B (C6F5) 3 and octanol, moiety will be distillation after the exchange, getting the gallic octyl ester. This method avoids the use of heavy metal catalyst, high yield, low cost, and is suitable for industrial scale production, the ester exchange after the end of the added metal ion adsorbent after the metal ion adsorption, distillation electronic level of gallic octyl ester.

Synthesis and in vitro antimalarial activity of alkyl esters of gallate as a growth inhibitor of plasmodium falciparum

This study is aimed to synthesize alkyl esters gallate and determine its in vitro antimalarial activity against parasite Plasmodium falciparum. Fourteen compounds of alkyl esters gallate were synthesized by esterification of the carboxyl group of gallic acid with a series of alkyl alcohols, as well as methoxylation of the hydroxy groups on the aromatic ring of gallic acid. Antimalarial activity of the synthesized alkyl esters gallate were expressed by IC50 value, with gallic acid as an original compound and artemisin as a positive control. Compared to gallic acid, eleven synthesized compounds of alkyl esters gallate, have a greater antimalarial activity against Plasmodium falciparum. On the other hand, three compounds, that are propyl gallate, butyl gallate and trimethoxy methyl gallate, showed a lower antimalarial activity. Moreover, compared to gallic acid (IC50: 194.86 mM) and artemisin (IC50: 0.5 mM), two synthesized compounds of alkyl gallates, namely methyl gallate and hexyl gallate exhibited the stronger antimalarial activity against Plasmodium falciparum, with IC50 value of 0.03 mM and 0.11 mM, respectively. Our result clearly demonstrated that methyl gallate and hexyl gallate as a promising candidate for the new antimalarial agents.

HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS

The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer.