944730-07-8

Upstream product

• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 944729-88-8 diethyl (7-methoxybenzo[d][1,3]dioxol-5-yl)methylphosphonate 
• 22934-60-7 6-(chloromethyl)-4-methoxybenzo[d][1,3]dioxole 
• 99-24-1 methyl galloate 
• 22934-58-3 methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate 
• 3934-86-9 methyl 3,4-dihydroxy-5-methoxybenzoate 
• 22934-59-4 (7-methoxybenzo[d][1,3]dioxol-5-yl)methanol 
• 1083-41-6 n-butyl gallate 
• 100-39-0 benzyl bromide 
• 121-33-5 vanillin 
• 108853-31-2 3-methoxy-4,5-methylenedioxybenzyl bromide 
• 108853-29-8 n-butyl 3,4-dihydroxy-5-methoxybenzoate 
• 108853-30-1 n-butyl 3-methoxy-4,5-methylenedioxybenzoate 

Relevant academic research and scientific papers

Synthesis and anti-proliterative in-vitro activity of two natural dihydrostilbenes and their analogues

A total synthetic route for two natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines, (3-(2-(7-methoxybenzo[d][1,3] dioxol-5-yl)ethyl)phenol 1a and 6-(3-hydroxyphenethyl)benzo[d][1,3]dioxol-4-ol 1b), which were isolated from Bulbophyllum odoratissimum Lind1, was developed via Wittig-Horner reaction. The natural products 1a and 1b were obtained in 28% and 20% overall yield, respectively. Additionally, nine analogues, 1c-1k, of the two natural dihydrostilbenes were synthesized and evaluated for their anti-proliferative activity against human SGC-7901, KB and HT-1080 cell lines by MTT assay. The activities of 1c and 1d were in the same range as those of the natural products 1a and 1b.

BIBENZYL DERIVATIVES FROM FRULLANIA SPECIES

Four novel bibenzyl derivatives; 3,4,3',4'-dimethylenedioxybibenzyl, 3,3'-dimethoxy-4,5-methylenedioxybibenzyl, 3,3'-dimethoxy-4,5-methylenedioxy-4'-hydroxybibenzyl and 3,3'-dihydroxy-4,5,4',5'-dimethylenedioxybibenzyl were isolated from three Frullania species of liverworts and their structures were determined by spectral evidence and synthesis. - Key Word Index: Frullania bonincola; F. davurica; F. diversitexta; F. ericoides; F. parvistipula; F. usamiensis; F. vethii, Frullaniaceae; Jungermanniales; Hepaticae; bibenzyls; sesquiterpenoids.