1083065-09-1 Usage
Uses
N-[(7R)-6,7-Dihydro-5-[(4-methoxyphenyl)methyl]-6-oxo-5H-dibenz[b,d]azepin-7-yl]-carbamic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl ester is an impurity in the synthesis of (S)-7-Amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for γ-secretase inhibitors for treatment of Alzheimer''s disease. Several γ-secretase inhibitors have been described that contain this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 1083065-09-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,3,0,6 and 5 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1083065-09:
(9*1)+(8*0)+(7*8)+(6*3)+(5*0)+(4*6)+(3*5)+(2*0)+(1*9)=131
131 % 10 = 1
So 1083065-09-1 is a valid CAS Registry Number.
1083065-09-1Relevant articles and documents
Improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for γ-secretase inhibitors
Hoffmann-Emery, Fabienne,Jakob-Roetne, Roland,Flohr, Alexander,Bliss, Fritz,Reents, Reinhard
experimental part, p. 6380 - 6382 (2010/02/28)
An improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one (1), involving a selective crystallization of epimeric menthylcarbamates for the resolution step followed by simultaneous cleavage of the carbamate and the lactam protecting group is desc
