108310-90-3Relevant academic research and scientific papers
A convenient synthesis of deoxynebularine phosphoramidite
Picken, Douglas,Gault, Vicki
, p. 937 - 939 (1997)
Enzyme catalysis by a cell free preparation from Lactobacillus leichmannii is used to accomplish the transformation of thymidine to deoxynebularine in the presence of purine. The resulting mixture of nucleosides is then converted to their 5'-dimethoxytrityl derivatives which are easily separated using conventional chromatography. Phosphitylation of the 5'-dimethoxytrityl-deoxynebularine then gives the phosphoramidite derivative suitable for incorporation into oligonucleotides.
CYCLIC DINUCLEOTIDES AS STING AGONISTS
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Paragraph 00402; 00405-00407, (2020/02/14)
Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1', X1, B1
