A convenient synthesis of deoxynebularine phosphoramidite

Article abstract of DOI:10.1080/07328319708006110

Enzyme catalysis by a cell free preparation from Lactobacillus leichmannii is used to accomplish the transformation of thymidine to deoxynebularine in the presence of purine. The resulting mixture of nucleosides is then converted to their 5'-dimethoxytrityl derivatives which are easily separated using conventional chromatography. Phosphitylation of the 5'-dimethoxytrityl-deoxynebularine then gives the phosphoramidite derivative suitable for incorporation into oligonucleotides.

Full text of DOI:10.1080/07328319708006110

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Nucleosides and Nucleotides
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A Convenient Synthesis of
Deoxynebularine Phosphoramidite
a
a
Douglas Picken & Vicki Gault
a
Link Technologies Limited , 2 Napier Court, Cumbernauld,
Glasgow, G68 OLG, U.K.
Published online: 16 Aug 2006.
To cite this article: Douglas Picken & Vicki Gault (1997) A Convenient Synthesis of
Deoxynebularine Phosphoramidite, Nucleosides and Nucleotides, 16:7-9, 937-939, DOI:
10.1080/07328319708006110
To link to this article: http://dx.doi.org/10.1080/07328319708006110
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