1083168-91-5

Basic information

• Product Name: 3-Chloro-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine
• Synonyms: 3-Chloro-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine;5-Chloro-6-methoxypyridine-3-boronic acid pinacol ester;(5-CHLORO-6-METHOXYPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;Pyridine, 3-chloro-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
• CAS NO: 1083168-91-5
• Molecular Formula: C₁₂H₁₇BClNO₃
• Molecular Weight: 269.53228
• Mol File: 1083168-91-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-Chloro-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine(1083168-91-5)
• EPA Substance Registry System: 3-Chloro-2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine(1083168-91-5)

Safety Data

• Hazardous Substances Data: 1083168-91-5(Hazardous Substances Data)

Usage

Uses

5-Chloro-6-methoxypyridine-3-boronic acid pinacol ester is used as pharmaceutical intermediate.

Upstream product

• 848366-28-9 5-bromo-3-chloro-2-methoxypyridine 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

Azaindazole bipyridine derivative myeloid cell proliferation inhibitor as well as preparation method and application thereof in pharmacy

The invention provides an azaindazole bipyridine derivative myeloid cell proliferation inhibitor shown as a formula I, wherein R1, R2 and R3 have the meanings defined in the specification of the invention. A compound in formula I can significantly inhibit proliferation and related disordersof myeloid cells represented by MOLM-16, HL-60, and MV-4-11. The formula I or salt thereof or the related pharmaceutical composition provided by the invention has excellent in-vivo and in-vitro inhibitory activity, good druggability, high bioavailability and no obvious damage to organs. Therefore, the compound shown in the formula I or the salt thereof and the related drug combination have huge clinical application prospects.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.