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1083168-93-7

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1083168-93-7 Usage

Description

Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate is a chemical compound derived from nicotinic acid, featuring a methoxy group and a boron-containing dioxaborolane functional group. It serves as a valuable intermediate in organic synthesis and pharmaceutical research, contributing to the development of complex molecules and new drugs.

Uses

Used in Pharmaceutical Research:
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate is used as a building block for the production of various pharmaceuticals, leveraging its unique structure and properties to facilitate the synthesis of biologically active compounds.
Used in Organic Synthesis:
In the field of organic synthesis, Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate is employed as an important reagent, enabling the creation of complex molecules through its versatile functional groups.
Used in Drug Development:
Methyl2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate is utilized in the development of new drugs, where its boron-containing dioxaborolane group plays a crucial role in enhancing the synthesis and properties of potential therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 1083168-93-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,3,1,6 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1083168-93:
(9*1)+(8*0)+(7*8)+(6*3)+(5*1)+(4*6)+(3*8)+(2*9)+(1*3)=157
157 % 10 = 7
So 1083168-93-7 is a valid CAS Registry Number.

1083168-93-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate

1.2 Other means of identification

Product number -
Other names 2-Methoxy-3-(carbomethoxy)pyridine-5-boronic acid, pinacol ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1083168-93-7 SDS

1083168-93-7Downstream Products

1083168-93-7Relevant articles and documents

Exploiting C–H borylation for the multidirectional elaboration of 2-halopyridines

Reuven, Jonathan A.,Salih, Omar A.,Sadler, Scott A.,Thomas, Carys L.,Steel, Patrick G.

, (2019/12/27)

Regioselectively polysubstituted pyridines can be efficiently accessed from 2-halopyridines via a sequence involving C–H borylation, Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution chemistry.

Iridium-catalyzed C-H borylation of pyridines

Sadler, Scott A.,Tajuddin, Hazmi,Mkhalid, Ibraheem A. I.,Batsanov, Andrei S.,Albesa-Jove, David,Cheung, Man Sing,Maxwell, Aoife C.,Shukla, Lena,Roberts, Bryan,Blakemore, David C.,Lin, Zhenyang,Marder, Todd B.,Steel, Patrick G.

supporting information, p. 7318 - 7327 (2014/11/07)

The iridium-catalysed C-H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodology for the preparation of pyridyl and related azinyl boronates can be challenged by low reactivity and propensity for rapid protodeborylation, particularly for a boronate ester ortho to the azinyl nitrogen. Competition experiments have revealed that the low reactivity is due to inhibition of the active catalyst through coordination of the azinyl nitrogen lone pair at the vacant site on the iridium. This effect can be overcome through the incorporation of a substituent at C-2. Moreover, when this is sufficiently electron-withdrawing protodeborylation is sufficiently slowed to permit isolation and purification of the C-6 boronate ester. Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring. This journal is the Partner Organisations 2014.

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