1083181-25-2

Usage

Uses

Used in Organic Synthesis:
2-Bromo-1H-pyrrolo[2,3-b]pyridine is utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable component in the development of new and effective compounds for different applications.
Used in Catalysts for Chemical Reactions:
2-Bromo-1H-pyrrolo[2,3-b]pyridine is also recognized for its potential use as a ligand for transition metal catalysts. In this capacity, 2-Bromo-1H-pyrrolo[2,3-b]pyridine can enhance the efficiency and selectivity of chemical reactions, contributing to advancements in the field of catalysis.
Used in Medicinal Chemistry:
2-Bromo-1H-pyrrolo[2,3-b]pyridine has been studied for its biological activity, indicating its potential for medicinal applications. Its unique structure may offer new avenues for drug discovery and development, particularly in the areas of pharmaceuticals and therapeutic agents.
Used in Research and Development:
In the scientific community, 2-Bromo-1H-pyrrolo[2,3-b]pyridine serves as a subject of research for understanding its properties, reactivity, and potential applications. This knowledge can lead to the creation of new methodologies and technologies in organic chemistry and related fields.

InChI:InChI=1S/C7H5BrN2/c8-6-4-5-2-1-3-9-7(5)10-6/h1-4H,(H,9,10)

Upstream product

• 1198416-32-8 C₁₄H₁₁BrN₂O₂S 
• 271-63-6 7-Azaindole 
• 138343-77-8 1-(tert-butoxycarbonyl)-1H-pyrrolo<2,3-b>pyridine 

Downstream Products

• 2580027-30-9 1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester 

Relevant academic research and scientific papers

Synthesis method of 1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester

The invention discloses a synthesis method of 1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester, and belongs to the field of medicinal chemistry. The synthesis method comprises the following steps: reacting 7-azaindole serving as a raw material with di-tert-butyl dicarbonate to synthesize 1H-pyrrolo[2,3b]pyridine-1-carboxylic acid tert-butyl ester, reacting the 1H-pyrrolo[2,3b]pyridine-1-carboxylic acid tert-butyl ester with n-butyl lithium and 1,2-dibromotetrafluoroethane at low temperature to synthesize 2-bromo-1H-pyrrolo[2,3-b]pyridine, synthesizing 2-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester, removing the protective group to obtain 2-bromo-1H-pyrrolo[2,3-b]pyridine, and reacting 2-bromo-1H-pyrrolo[2,3-b]pyridine with bi-pinacol borate under the catalytic action of transition metals to obtain the target product. The raw materials and reagents are cheap and easy to obtain, reaction conditions are mild, the safety is high, the cost is low, and the preparation method is easily applied to industrial batch production.

COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.