2580027-30-9 Usage
Molecular structure
1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester has a unique molecular structure that includes a boronic acid group and a pinacol ester group.
Boronic acid derivative
It is a derivative of boronic acid, which is a compound containing a boron atom bonded to three hydroxyl groups.
Pinacol ester
It is a pinacol ester, which is a type of ester formed from the reaction of a boronic acid with pinacol (a diol).
Organic synthesis tool
It is a valuable tool in organic synthesis due to its ability to participate in various chemical reactions, such as Suzuki-Miyaura cross-coupling reactions.
Building block
Boronic acids are important building blocks in the preparation of pharmaceuticals and agrochemicals.
Biological activity
The presence of the pyrrolo[2,3-b]pyridine moiety in this compound gives it potential biological activity, making it an interesting target for medicinal chemistry research.
Versatile compound
1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester is a versatile compound with both synthetic and potentially therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 2580027-30-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,5,8,0,0,2 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2580027-30:
(9*2)+(8*5)+(7*8)+(6*0)+(5*0)+(4*2)+(3*7)+(2*3)+(1*0)=149
149 % 10 = 9
So 2580027-30-9 is a valid CAS Registry Number.
2580027-30-9Relevant articles and documents
Synthesis method of 1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester
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Paragraph 0043; 0052-0057, (2021/01/11)
The invention discloses a synthesis method of 1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester, and belongs to the field of medicinal chemistry. The synthesis method comprises the following steps: reacting 7-azaindole serving as a raw material with di-tert-butyl dicarbonate to synthesize 1H-pyrrolo[2,3b]pyridine-1-carboxylic acid tert-butyl ester, reacting the 1H-pyrrolo[2,3b]pyridine-1-carboxylic acid tert-butyl ester with n-butyl lithium and 1,2-dibromotetrafluoroethane at low temperature to synthesize 2-bromo-1H-pyrrolo[2,3-b]pyridine, synthesizing 2-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester, removing the protective group to obtain 2-bromo-1H-pyrrolo[2,3-b]pyridine, and reacting 2-bromo-1H-pyrrolo[2,3-b]pyridine with bi-pinacol borate under the catalytic action of transition metals to obtain the target product. The raw materials and reagents are cheap and easy to obtain, reaction conditions are mild, the safety is high, the cost is low, and the preparation method is easily applied to industrial batch production.
