108319-06-8

Basic information

• Product Name: TEMAFLOXACIN
• Synonyms: Teflox;6-Fluoro-1-(2,4-difluorophenyl)-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;TeMafloxacin HCl;TEMAFLOXACIN;AKOS 92085;1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl) -4-oxo-3-quinoline-carboxylic acid;1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid hydrochloride;A-62254
• CAS NO: 108319-06-8
• Molecular Formula: C₂₁H₁₈F₃N₃O₃
• Molecular Weight: 417.38
• Mol File: 108319-06-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 608.9°Cat760mmHg
• Flash Point: 322.1°C
• Appearance: /
• Density: 1.3372 (estimate)
• Vapor Pressure: 1.11E-15mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: TEMAFLOXACIN(CAS DataBase Reference)
• NIST Chemistry Reference: TEMAFLOXACIN(108319-06-8)
• EPA Substance Registry System: TEMAFLOXACIN(108319-06-8)

Safety Data

• Hazardous Substances Data: 108319-06-8(Hazardous Substances Data)

Usage

Description

Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.

Uses

Temafloxacin is an antimicrobial quinolone drug.

Brand name

Omniflox (Abbott);8Omniflox 8Teflox 8Temac.

World Health Organization (WHO)

Temafloxacin, a quinolone antimicrobial, was introduced in 1991. Shortly afterwards, its use became associated with severe adverse effects, including hypoglycaemia, haemolytic anaemia, renal failure, hepatitis and anaphylactic reactions. This led to its worldwide withdrawal by the manufacturer.

InChI:InChI=1/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)

Related news

In vitro susceptibility to TEMAFLOXACIN (cas 108319-06-8) in female genital tract Bacteroides isolates08/26/2019

Agar dilution susceptibility testing of temafloxacin, cefotetan, clindamycin, and ciprofloxacin was performed in 103 genital tract isolates of Bacteroides. The respective minimum inhibitory concentration inhibiting 90% of the strains tested were temafloxacin, 4 μg/ml; cefotetan, 256 μg/ml; cli...detailed

Comparative pharmacokinetics of ciprofloxacin and TEMAFLOXACIN (cas 108319-06-8) in humans: A review08/25/2019

Temafloxacin is a new antibacterial agent of the fluoroquinolone group. In comparison with ciprofloxacin, the current leading quinolone, temafloxacin shows higher and longer lasting plasma concentrations after equivalent doses due to an almost complete gastrointestinal absorption and a lower tot...detailed

Relevant articles and documents

NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES

The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.