1083275-46-0

Basic information

• Product Name: 5-methyl-1-(4-methylphenyl)-4-[(4-methylphenyl)sulfonyl]-1H-1,2,3-triazole
• Synonyms: 5-methyl-1-(4-methylphenyl)-4-[(4-methylphenyl)sulfonyl]-1H-1,2,3-triazole
• CAS NO: 1083275-46-0
• Molecular Weight: 327.407
• Mol File: 1083275-46-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-methyl-1-(4-methylphenyl)-4-[(4-methylphenyl)sulfonyl]-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-1-(4-methylphenyl)-4-[(4-methylphenyl)sulfonyl]-1H-1,2,3-triazole(1083275-46-0)
• EPA Substance Registry System: 5-methyl-1-(4-methylphenyl)-4-[(4-methylphenyl)sulfonyl]-1H-1,2,3-triazole(1083275-46-0)

Safety Data

• Hazardous Substances Data: 1083275-46-0(Hazardous Substances Data)

Upstream product

• 2725-60-2 1-(p-methylphenylsulfonyl)-1-diazopropan-2-one 
• 106-49-0 p-toluidine 
• 5366-49-4 4-toluenesulfonylacetone 
• 2101-86-2 p-methylazidobenzene 

Relevant articles and documents

α-Diazo-β-oxosulfones as Partners in the Wolff 1,2,3-Triazole Synthesis and the Wolff Rearrangement in the Presence of Aromatic Amines

The readily available α-diazo-β-oxosulfones have been employed, for the first time, in the Wolff cyclocondensation with aromatic amines promoted by 1.5-fold excess of TiCl4. The reaction was found to be general (as illustrated by 15 product examples) and resulted in moderate yields of medicinally relevant sulfonyl 1,2,3-triazoles. Excluding the Lewis acid promoter resulted in a clean and high-yielding formation of α-sulfonyl acetanilides resulting from the thermal Wolff rearrangement and trapping of the ketene intermediate with an aniline molecule.