1083302-41-3

Upstream product

• 1083302-39-9 2,2,2-trifluoro-N-((1R,4R)-7-fluoro-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetamide 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 2840-44-0 7-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 1083302-37-7 (R)-2,2,2-trifluoro-N-(7-fluoro-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)acetamide 
• 1083302-35-5 (R)-2,2,2-trifluoro-N-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)acetamide 
• 1083302-32-2 (R)-1-azido-7-fluoro-1,2,3,4-tetrahydronaphthalene 
• 1055949-62-6 (R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine 
• 1083302-30-0 (S)-7-fluoro-1-tetralol 

Downstream Products

• 1083302-43-5 (1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine 
• 1083302-71-9 N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine 
• 1083302-74-2 N₄-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)pyrimidine-4,5-diamine 
• 1141856-05-4 9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one 
• 1083302-77-5 9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7H-purin-8(9H)-one 

Relevant academic research and scientific papers

2,7,9-SUBSTITUTED PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula (I).