1055949-62-6

Usage

Uses

Used in Pharmaceutical Research and Development:
(R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine is used as a building block for drug synthesis, contributing to the development of new pharmaceutical compounds. Its unique structure allows for the exploration of novel drug candidates with potential therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine is used as a valuable tool for studying structure-activity relationships and drug design. Its fluorine atom and naphthalene ring provide insights into the reactivity and behavior of amines in chemical processes.
Used in Chemical Process Studies:
(R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine's unique structure and properties make it a useful tool for understanding the reactivity and behavior of amines in various chemical processes. This knowledge can be applied to optimize reaction conditions and improve the synthesis of related compounds.

Upstream product

• 2840-44-0 7-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 1083302-30-0 (S)-7-fluoro-1-tetralol 
• 215315-62-1 7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine 
• 1083302-32-2 (R)-1-azido-7-fluoro-1,2,3,4-tetrahydronaphthalene 

Downstream Products

• 1083302-43-5 (1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine 
• 1083302-41-3 N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2,2,2-trifluoroacetamide 
• 1083302-71-9 N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine 
• 1083302-74-2 N₄-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)pyrimidine-4,5-diamine 
• 1141856-05-4 9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one 
• 1083302-77-5 9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7H-purin-8(9H)-one 

Relevant academic research and scientific papers

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

A library of 132 racemic chiral amines (α-substituted methylbenzylamines, benzhydrylamines, 1,2,3,4-tetrahydronaphthylamines (THNs), indanylamines, allylic and homoallylic amines, propargyl amines) was screened against the most versatile monoamine oxidase (MAO-N) variants D5, D9 and D11. MAO-N D9 exhibited the highest activity for most substrates and was applied to the deracemisation of a comprehensive set of selected primary amines. In all cases, excellent enantioselectivity was achieved (e.e. >99%) with moderate to good yields (55–80%). Conditions for the deracemisation of primary amines using a MAO-N/borane system were further optimised using THN as a template addressing substrate load, nature of the enzyme preparation, buffer systems, borane sources, and organic co-solvents.

2,7,9-SUBSTITUTED PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula (I).