1083309-31-2

Basic information

• Product Name: C₃₃H₄₁N₅O₉
• Synonyms: C₃₃H₄₁N₅O₉
• CAS NO: 1083309-31-2
• Molecular Weight: 651.717
• Mol File: 1083309-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₄₁N₅O₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₄₁N₅O₉(1083309-31-2)
• EPA Substance Registry System: C₃₃H₄₁N₅O₉(1083309-31-2)

Safety Data

• Hazardous Substances Data: 1083309-31-2(Hazardous Substances Data)

Upstream product

• 1083309-28-7 methyl 4-(3-hydroxypropyl)-7-tert-butoxycarbonyl-5-oxo-4,7-diazaspiro[2.5]octane-8-carboxylate 
• 10065-79-9 N₁,N₂-bis(benzyloxycarbonyl)guanidine 

Downstream Products

• 1083309-33-4 C₂₈H₃₃N₅O₇ 

Relevant articles and documents

High yielding selective access to spirocyclopropanated 5-oxopiperazine-2- carboxylates and 1,4-diazepane-2,5-diones from methyl 2-chloro-2- cyclopropylideneacetate

The 2-spirocyclopropanated methyl 5-oxopiperazine-2-carboxylate 3 and the 3-spirocyclopropanated 6-chloro-1,4-diazepane-2,5-dione 4 could both be prepared at choice in 93 and 88% yield, respectively, from methyl 2-chloro-2- cyclopropylideneacetate (1) in a sequence of Michael addition of 3-benzyloxypropylamine, peptide coupling with N-Boc-glycine, Boc-group removal and cyclization. Transformation of the benzyloxypropyl side chain, peptide coupling with N-Boc-(S)-asparagine, deprotection and repeated cyclization led to the octahydro[2H]pyrazino[1,2-a]pyrazinetrione scaffold 10 containing a rigidified mimic of a tripeptide with a DGR motif. The overall yield of 11 after deprotection of 10 (a total of 13 steps in 8 distinct operations) was 30%. The Royal Society of Chemistry 2008.