10065-79-9Relevant articles and documents
Total Synthesis of Teixobactin
Giltrap, Andrew M.,Dowman, Luke J.,Nagalingam, Gayathri,Ochoa, Jessica L.,Linington, Roger G.,Britton, Warwick J.,Payne, Richard J.
, p. 2788 - 2791 (2016)
The first total synthesis of the cyclic depsipeptide natural product teixobactin is described. Synthesis was achieved by solid-phase peptide synthesis, incorporating the unusual l-allo-enduracididine as a suitably protected synthetic cassette and employing a key on-resin esterification and solution-phase macrolactamization. The synthetic natural product was shown to possess potent antibacterial activity against a range of Gram-positive pathogenic bacteria, including a virulent strain of Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA).
Orthoamides by selective borohydride reduction of N,N′,N″-triacyl- and N,N′,N″-tri(alkoxycarbonyl)-guanidines
Davis, Matthew C.,Groshens, Thomas J.
supporting information, p. 427 - 431 (2019/01/05)
N,N′,N″-Triacylguanidines and N,N′,N″-tri(alkoxycarbonyl)guanidines were prepared and reduced with borohydride salts in a mixture of tetrahydrofuran and acetic acid to give triacyl and tri(alkoxycarbonyl) orthoamides in yields of 40–85%. However, similar
Process for the preparation of substituted pyrimidine derivatives
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Page/Page column 18, (2010/02/16)
The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.