108334-73-2

Basic information

• Product Name: methyl 2-Hydroxy-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate
• CAS NO: 108334-73-2
• Molecular Weight: 234.208
• Mol File: 108334-73-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-Hydroxy-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-Hydroxy-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate(108334-73-2)
• EPA Substance Registry System: methyl 2-Hydroxy-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate(108334-73-2)

Safety Data

• Hazardous Substances Data: 108334-73-2(Hazardous Substances Data)

Upstream product

• 78939-37-4 4-oxo-pent-2-enedioic acid dimethyl ester 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

PdII-catalyzed conjugate addition of boronic acids to ketoglutaconic esters toward the synthesis of functionalized pyridazin-3(2H)-ones with neuroprotective activity

The development of the regioselective conjugate addition of boronic acids to ketoglutaconic esters under transition metal catalysis is reported. Among the different catalysts tested for this transformation, the dicationic Pd II catalysts generated with Pd(OCOCF3)2, dppben, and HBF4 performed best in terms of yields, regioselectivities and avoidance of Heck-type by-products. The resulting 4-aryl-2-oxopentadienoates were transformed into pyridazin-3(2H)-ones, potentially useful for the therapy of neurodegenerative diseases. These compounds simultaneously exhibited β-secretase activity, inhibition of β-amyloid (βA) aggregation, and disaggregation of pre-formed βA fibrils, and also had a good scavenging profile for intracellular reactive oxygen species (ROS). Copyright