108360-76-5

Upstream product

• 15387-45-8 Boc-Gln-ONp 
• 151782-02-4 Boc-Gln-Val-OPac 
• 111970-72-0 2-oxo-2-phenylethyl (tert-butoxycarbonyl)-L-valinate 
• 83316-95-4 2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate 
• 83316-94-3 H-Val-OPac 
• 83316-92-1 glycine phenacyl ester 
• 171661-91-9 N-(N-(1,1-dimethylethoxycarbonyl)-L-glutaminyl)-L-valine 

Relevant academic research and scientific papers

Design of the Synthetic Route for Peptides and Proteins Based on the Solubility Prediction Method. I. Synthesis and Solubility Properties of Human Proinsulin C-Peptide Fragments

The usefulness of the solubility prediction method is demonstrated using relatively small peptide fragments of human proinsulin C-peptide.The propriety of the solubility prediction method for peptides having polar side chains is also examined in the following respects: (1) Peptide intermediates smaller than a heptapeptide have high solubility regardless of their c> values; (2) the c> values of peptide intermediates are useful for judging solubility of peptide intermediates equal to or larger than an octapeptide level; (3) the Pro residue in a central position of a peptide chain is effective for increasing peptide solubility; and (4) there is critical chain length for peptide insolubility caused by a β-sheet aggregation.A strategy suitable for the design of the synthetic route or human proinsulin C-peptide is subsequently discussed on the basis of the solubility prediction of peptide intermediates.