108379-93-7

Basic information

• Product Name: α-acetoxy-3-methoxyacetophenone
• Synonyms: α-acetoxy-3-methoxyacetophenone
• CAS NO: 108379-93-7
• Molecular Weight: 208.214
• Mol File: 108379-93-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: α-acetoxy-3-methoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: α-acetoxy-3-methoxyacetophenone(108379-93-7)
• EPA Substance Registry System: α-acetoxy-3-methoxyacetophenone(108379-93-7)

Safety Data

• Hazardous Substances Data: 108379-93-7(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 1711-05-3 m-anisoyl chloride 
• 127-08-2 potassium acetate 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 57965-21-6 4,4,4-trifluoro-1-(3-methoxyphenyl)butane-1,3-dione 
• 766-85-8 3-methoxy-1-iodobenzene 
• 13831-31-7 Acetoxyacetyl chloride 
• 349537-50-4 N-(1-(3-methoxyphenyl)vinyl)acetamide 

Downstream Products

• 87428-52-2 2-hydroxy-3'-methoxyacetophenone 
• 74973-42-5 3-(3-methoxybenzoyl)-1-phenylpropanol 
• 76934-64-0 4-Hydroxy-4-(4-methoxy-phenyl)-1-(3-methoxy-phenyl)-butan-1-one 
• 32345-63-4 1-(3-methoxyphenyl)-1,2-ethanediol 

Relevant articles and documents

Copper(II) and 2,2'-biimidazole-promoted novel reaction of 4,4,4-trifluoro-1-phenylbutane-1,3-diones with iodobenzene diacetate

A new and efficient way was developed to carry out the reaction of 4,4,4-trifluoro-1-phenylbutane-1,3-dione with iodobenzene diacetate under the assistance of Cu(II) and 2,2'-biimidazole at a low temperature in excellent yield. 2-Acetoxyacetophenone was obtained unexpectedly.

Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process

Hydrogen peroxide and anhydride mediated transformation of enamides to afford substituted α-acyloxy ketones is described. This transition-metal-free cascade reaction has a broad substrate scope and high efficiency. The acyl intramolecular migration procedure successfully achieved this acyloxylation process under mild conditions and increased the atom efficiency.

Facile synthesis of glycol metabolites of phenethylamine drugs

High yields of potential glycol metabolites of p-synephrine, epinephrine, octopamine, and normacromerine can be obtained from the readily available monosubstituted and disubstituted acetophenones. The general procedure involves alpha-bromination followed by displacement with acetate ion and reduction with lithium aluminum hydride. Yields ranged from 46 to 91%. Furthermore, the procedure minimizes some problems inherent in aromatic glycol synthesis which include dimerization and pinacol-pinacolone rearrangement.