108381-49-3

Basic information

• Product Name: 1-(2-methoxyphenyl)-4-(2-(2-aminopyrimidinyl)ethyl)piperazine
• CAS NO: 108381-49-3
• Molecular Weight: 313.403
• Mol File: 108381-49-3.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-methoxyphenyl)-4-(2-(2-aminopyrimidinyl)ethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxyphenyl)-4-(2-(2-aminopyrimidinyl)ethyl)piperazine(108381-49-3)
• EPA Substance Registry System: 1-(2-methoxyphenyl)-4-(2-(2-aminopyrimidinyl)ethyl)piperazine(108381-49-3)

Safety Data

• Hazardous Substances Data: 108381-49-3(Hazardous Substances Data)

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 40255-48-9 1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine 

Relevant articles and documents

Short and efficient syntheses of analogues of way-100635: New and potent 5-HT1A receptor antagonists

Simple syntheses of four new and potent analogues of the 5-HT1A receptor ligand, WAY-100635 are described, namely the 6- pyridinyl)-fluoro-, the pyrimidine- and the 5-pyridinyl)-bromo-analogues. The first three analogues were obtained by aromat

The development of additional radioligands of varying pharmacokinetics for the 5-HT1A receptor

Six compounds have been prepared to further probe the structure activity relationships based on the 5-HT1A receptor ligand, WAY 100635. The goal is to obtain a series of radiotracers with varying pharmacokinetic properties. Substitution of a pyrimidine moiety, increased the specific binding ratio in the phenylcarboxamide series, but decreased the ratio in the cyclohexanecarboxamide series. A series of compounds with varying pharmacokinetic properties are now available to study a range of properties involving 5-HT1A receptor binding.

Method for treating urinary obstruction

A method for treating urinary obstruction by administering a 2-(4-phenyl-1-piperazinylalkyl)aminopyrimidine derivative represented by the formula STR1 wherein R 1 and R 3 may be the same or different and independently represent hydrogen, halogen, an amino group, a hydroxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkoxy group, or a straight or branched chain hydroxy-lower alkyl group, R 2 represents hydrogen, halogen, a carboxyl group, a straight or branched chain lower alkyl group, a straight or branched chain lower alkylcarbonyl group, or a straight or branched chain lower alkyloxycarbonyl group, R 4 and R 5 may be the same or different and independently represent hydrogen, halogen, a straight or branched chain lower alkyl group, or a straight or branched chain lower alkoxy group, and n represents an integer of 2 to 6 or a pharmaceutically acceptable acid addition salt thereof to a mammal including a human afflicted with urinary obstruction. The aminopyrimidine derivatives have a selective activity on the α 1 -adrenoceptors in the urinary tracts.