108399-92-4

Upstream product

• 13242-53-0 acetobromomannose 
• 88261-81-8 methyl 2,4,6-tri-O-benzyl-3-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-α-D-mannopyranoside 
• 73045-58-6 methyl 2,4,6-tri-O-benzyl-α-D-mannopyranoside 

Downstream Products

• 108399-98-0 methyl 2,4,6-tri-O-benzyl-3-O-α-D-talopyranosyl-α-D-mannopyranoside 
• 108399-94-6 methyl 2,4,6-tri-O-benzyl-3-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-mannopyranosyl>-α-D-mannopyranoside 
• 108399-96-8 methyl 2,4,6-tri-O-benzyl-3-O-<6-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-α-D-talopyranosyl>-α-D-mannopyranoside 
• 108399-95-7 (3aS,4S,6R,7aR)-4-((2R,3R,4S,5S,6S)-3,5-Bis-benzyloxy-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-4-yloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-one 
• 108399-97-9 methyl 2,4,6-tri-O-benzyl-3-O-(2,3-O-isopropylidene-α-D-talopyranosyl)-α-D-mannopyranoside 
• 108399-93-5 methyl 2,4,6-tri-O-benzyl-3-O-<6-O-(tert-butyldiphenylsilyl)-α-D-mannopyranosyl>-α-D-mannopyranoside 

Relevant academic research and scientific papers

LYSOSOMAL-ENZYME TARGETING: THE PHOSPHORYLATION OF SYNTHETIC D-MANNOSYL SACCHARIDES BY UDP-N-ACETYLGLUCOSAMINE:LYSOSOMAL-ENZYME N-ACETYLGLUCOSAMINE-PHOSPHOTRANSFERASE FROM RAT-LIVER MICROSOMES AND FIBROBLASTS

Phosphorylation of the D-mannose residues of lysosomal-enzymes is essential for the uptake and intracellular transport of these enzymes to lysosomes.The GlcNAc-P-transferase which is involved in the phosphorylation reaction seems to recognize a signal, probably a protein conformation, common to many lysosomal enzymes.To evaluate the role of the carbohydrate portion of the enzyme in these phosphorylation reactions, the acceptor specificity of GlcNAc-P-transferase from rat-liver microsomes and fibroblasts was examined with the aid of synthetic D-mannosyl disaccharides and derivatives that are closely related to the high-mannose type of oligosaccharides.Four methyl D-mannobiosides were synthesized, and their structures were established by 13C-n.m.r. spectroscopy.Of all the D-mannosyl saccharides tested, α-D-Man-(1->2)-α-D-Man-(1->OMe) was found to be the best acceptor, thereby suggesting that oligosaccharide structure may also have a role to play in recognition by this enzyme.