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• 109-65-9 1-bromo-butane 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 542-69-8 1-iodo-butane 

Relevant academic research and scientific papers

Piezochromic luminescence and aggregation induced emission of 9,10-bis[2-(2-alkoxynaphthalen-1-yl)vinyl]anthracene derivatives

Four derivatives of 9,10-bis[2-(2-alkoxynaphthalen-1-yl)vinyl]anthracene (BNAs) were designed, successfully synthesized and characterized by spectrofluorometer, powder wide-angle X-ray diffraction (PXRD) and differential scanning calorimetry experiments (DSC), etc. It was found that these compounds exhibited aggregation-induced emission phenomenon. Moreover, these target compounds displayed reversible color change from yellow to orange upon pressing and annealing process. Interestingly, all of BNAs obviously presented red-shifted piezofluorochromic (PFC) properties and behaved mainly length dependence of alkoxy group, in which, BNA displayed the largest PFC spectral shift (ΔlPFC?=?26?nm). The PXRD profiles demonstrated the transformation from crystalline to amorphous state upon grinding, and the mechanism of PFC behaviors was proposed. Thus, changing the length of alkoxyl chain could be an alternative way to tune their PFC behaviors.

Synthesis, characterization, and anti-cancer activity of new chalcone derivatives containing naphthalene and fluorine moieties

In recent years, chalcones and their derivatives have become the focus of global scientists due to increasing evidence reported towards their potency in antitumor and anti-cancer. Here, the chalcones designed and synthesized in our present study were derived from the derivatives of naphthaldehyde and acetophenone. Both these precursors have been reported in demonstrating a certain degree of anticancer property. Also, the substituents on these precursors such as hydroxyl, methoxy, prenyl, and chloro were shown able to enhance the anticancer efficiency. Hence, it is the interest of the current study to investigate the anticancer potential of the hybrid molecules (chalcones) consisting of these precursors with different alkoxy substituents and with or without the fluorine moiety. Two series of chalcone derivatives were designed, synthesized, and characterized using the elemental analysis, IR, 1H and 13C NMR spectroscopy, subsequently evaluated for their anti-cancer activity. Interestingly, the results showed that the fluorinated chalcones 11–15 exhibited stronger cytotoxic activity towards the breast cancer cell lines (4T1) compared to non-fluorinated chalcone derivatives. Remarkably, the selectivity index obtained for these fluorinated chalcones derivatives against the breast cancer 4T1 cell line was higher than those exhibited by cisplatin, which is one of the most frequently deployed chemotherapy agents in current medical practice. These findings could provide an insight towards the potential of fluorinated chalcones being developed as an anti-cancer agent with moderate activity towards breast cancer cell and low inhibition of fibroblast cell at a concentration of 100 μM.

Alkoxy substituted D-π-A dimethyl-4-pyrone derivatives: Aggregation induced emission enhancement, mechanochromic and solvatochromic properties

Three series of D-π-A 2,6-dimethyl-4-pyrone-cored derivatives were designed and synthesized. Evaluation by spectroscopic methods indicated that all the compounds exhibited aggregation-induced emission enhancement (AIEE) effect and solvatochromism. The experimental results revealed that the restriction of intramolecular rotation is the key element for showcasing the AIEE phenomenon. Moreover, all of the compounds presented red-shifted mechanochromic behavior, the extent of the red-shift was mainly dependent on the position and length of alkoxyl group. The PXRD and DSC profiles demonstrated a transformation from crystalline to amorphous state upon grinding. The D-A strategy introduced in this work could facilitate the development and application of ingenious mechanochromic materials.

NOVEL CERCOSPORAMIDE DERIVATIVE

The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes. A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R1 represents a hydrogen atom or a C1-C6 alkyl group, R2 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 halogenated alkyl group, R3 represents a hydrogen atom or a C1-C6 alkyl group, R4 represents a C6-C10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a C2-C6 alkenyloxy group, a C2-C6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.