108409-83-2 Usage
Uses
Used in Pharmaceutical Research:
2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is used as a research compound for its ability to inhibit Wnt/β-catenin and PPARγ and δ activity. This makes it a valuable tool for studying the roles of these pathways in various diseases and conditions.
Used in Cancer Research:
In the field of cancer research, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is used as an inhibitor of Wnt/β-catenin signaling, which plays a crucial role in the development and progression of various types of cancer. By blocking this signaling pathway, it can help in the development of novel therapeutic strategies for cancer treatment.
Used in Drug Development:
2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is used as a lead compound in the development of new drugs targeting Wnt/β-catenin and PPAR pathways. Its ability to inhibit the recruitment of co-activators β-catenin and GRIP1 makes it a promising candidate for the development of drugs with potential applications in treating cancer and other diseases associated with the dysregulation of these pathways.
Used in Cell Biology Research:
In cell biology research, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is used as a tool to study the migration and growth of various cancer cell lines, including breast, colon, lung, and liver. Its inhibitory effects on Wnt/β-catenin signaling can provide insights into the cellular mechanisms underlying these processes and help in the development of targeted therapies.
Used in Chemical Synthesis:
2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide can also be used as a starting material or intermediate in the synthesis of other related compounds with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. Its unique chemical structure and properties make it a versatile building block for the development of new molecules with diverse biological activities.
Biochem/physiol Actions
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.
References
1) Handeli et al. (2008), A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities; Mol. Cancer Ther., 7 521
2) Iida et al. (2012), FH535 inhibited migration and growth of breast cancer cells; PLoS One, 7 e44418
3) Frewer et al. (2013), A role for WISP2 in colorectal cancer cell invasion and motility; Cancer Genomics Proteomics, 10 187
4) Polk et al. (2012), FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling; Int. J. Toxicol., 31 380
5) Morita and Hayashi (2018), Tumor Progression is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis; Mol. Cancer Res. 16(5) 880
Check Digit Verification of cas no
The CAS Registry Mumber 108409-83-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,4,0 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 108409-83:
(8*1)+(7*0)+(6*8)+(5*4)+(4*0)+(3*9)+(2*8)+(1*3)=122
122 % 10 = 2
So 108409-83-2 is a valid CAS Registry Number.
