108436-98-2Relevant academic research and scientific papers
Scaleable processes for the synthesis of (-)-β-d-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)-β-d-2-aminopurine dioxolane (APD)
Zhou, Longhu,Coats, Steven J.,Zhang, Hongwang,Shi, Junxing,Bobeck, Drew R.,Schinazi, Raymond F.
, p. 5738 - 5743 (2012)
An efficient and scalable synthesis of (-)-DAPD and (-)-APD has been developed. We discovered that t-butyl cyanoacetate can be used as a new additive for the sugar nucleoside base coupling step en route to DAPD with improved β-selectivity and an isolated yield four-fold greater than the original process scale method. Using this new process, (-)-DAPD has been prepared on greater than 20 g scale. In the synthesis of (-)-APD, a key enzyme-catalyzed hydrolysis reaction afforded the water soluble deprotected α-anomer while leaving the β-anomer completely untouched.
MONOPHOSPHATE PRODRUGS OF DAPD AND ANALOGS THEREOF
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Page/Page column 25, (2012/06/16)
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV and HBV, in human patients or other animal hosts. The compounds are certain 6-substituted-2-amino-purine di
