Welcome to LookChem.com Sign In|Join Free
  • or


Post Buying Request

999-97-3 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
99% 1,1,1,3,3,3-Hexamethyldisilazane
Cas No: 999-97-3
No Data 150 Kilogram 20 Metric Ton/Month Chiye Organic Silicon Material (Shanghai) Co.,Ltd. Contact Supplier
High quality 999-97-3 1,1,1,3,3,3-Hexamethyldisilazane
Cas No: 999-97-3
USD $ 1300.0-1600.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Cas No: 999-97-3
USD $ 20.0-30.0 / Gram 10 Gram 2000 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
High quality Hexamethyldisilazane CAS 999-97-3 supplied by Chinese manufacturer
Cas No: 999-97-3
USD $ 46.0-46.0 / Kilogram 1 Kilogram 300 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
High Quality 99% 999-97-3 Hexamethyldisilazane Manufacturer
Cas No: 999-97-3
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
ISO certificate Hexamethyldisilazane / HMDS
Cas No: 999-97-3
No Data 1 Kilogram 200 Metric Ton/Month Wuhan Kemi-Works Chemical Co., Ltd Contact Supplier
Amadis Chemical offer CAS#999-97-3;CAT#A846118
Cas No: 999-97-3
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Hexamethyldisilazane CAS: 999-97-3
Cas No: 999-97-3
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
999-97-3 Hexamethyldisilazane
Cas No: 999-97-3
USD $ 8900.0-8900.0 / Gram 1 Gram 200 Gram/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
Hot sale Hexamethyldisilazane 99% min CAS 999-97-3
Cas No: 999-97-3
No Data 100 Gram 20000 Kilogram/Day Hubei XinRunde Chemical Co., Ltd Contact Supplier

999-97-3 Usage


ChEBI: An N-silyl compound obtained from ammonia by replacement of two of the hydrogens with trimethylsilyl groups. Hexamethyldisilazane is a derivatisation agent used in gas chromatography mass spectrometry applications.

General Description

A liquid. Boiling point of 260°F. Flash point 77°F. May be toxic by ingestion. Irritates skin and eyes. Vapors are heavier than air. May emit highly toxic nitrogen oxide fumes when heated to decomposition. Used to make other chemicals.


A reagent for the preparation of trimethylsilyl derivatives.


Hexamethyldisilazane is a bulk organo silicon compound, being a quite useful silanizing agent. It is a reagent for the preparation of trimethylsilyl derivatives. It can be used for silanizing the surface of silicon water, cellulose. It can also be used to dehydrate cells of biomaterials for scanning electron microscopy (SEM). The hexamethyldisilazane coatings on various nanoparticles make them be resistant to water contamination and flocculation during synthesis. It can also be used as a modifier to control the shape, formation of agglomerates surface area and pore size of silica particles. Moreover, it is an adhesion promoter for photoresist in photolithography, and is also useful in the pyrolysis-gas chromatography-mass spectrometry to enhance the detectability of compounds with polar functional groups.

Reactivity Profile

Hexamethyldisilazane reacts with many carbonyl containing organic compounds to generate gaseous ammonia. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.


Deactivation of chromatographic support materials. In electronic industry as an adhesion promoter for photoresists on silicon.

Air & Water Reactions

Highly flammable. Moisture sensitive.


Deng, Xiang. "Hexamethyldisilazane." Synlett 2011.06(2011):881-882. Chiavari, G, D. Fabbri, and S. Prati. "Gas chromatographic-mass spectrometric analysis of products arising from pyrolysis of amino acids in the presence of hexamethyldisilazane." Journal of Chromatography A922.1–2(2001):235-241. Nation, J. L. "A new method using hexamethyldisilazane for preparation of soft insect tissues for scanning electron microscopy." Stain Technology 58.6(1983):347-51. http://www.sigmaaldrich.com/catalog/product/sial/52619? lang=en?ion=US http://www.sigmaaldrich.com/catalog/product/aldrich/40215? lang=en?ion=US http://www.sigmaaldrich.com/catalog/product/sial/86944? lang=en?ion=US

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.


Flammable, moderate fire risk.

Chemical Properties

Colorless liquid

Purification Methods

A possible impurity is Me3SiCl. Wash it well with pet ether and fractionate it through a vacuum jacketed column packed with Helipac using a reflux ratio of 10:1. [Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4014.]


Hexamethyldisilazane mainly used as methyl silane alkylation (such as amikacin, penicillin, cephalosporins and kinds of penicillin derivatives), hydroxyl protectants of antibiotics. It is used as surface treatment agent of diatomite, white carbon black, titanium and blond additives of photoresist in the semiconductor industry. It is used as treatment agent of tearing strength resistance. It is used as a solvent in organic synthesis and organometallic chemistry. It is used as an adhesion promoter for photoresist in photolithography. it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.


Hexamethyldisilazane(HMDS) is an extremely versatile and strong silylating agent. It is primarily used for the protection of sensitive functional groups during chemical synthesis.One of the advantages of Hexamethyldisilazane over chlorosilanes is that no base is needed as a hydrochloric acid acceptor. It produces ammonia which escapes easily from the reaction mixture during silylation.

999-97-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (H0089)  1,1,1,3,3,3-Hexamethyldisilazane  >96.0%(GC) 999-97-3 10mL 80.00CNY Detail
TCI America (H0089)  1,1,1,3,3,3-Hexamethyldisilazane  >96.0%(GC) 999-97-3 25mL 100.00CNY Detail
TCI America (H0089)  1,1,1,3,3,3-Hexamethyldisilazane  >96.0%(GC) 999-97-3 100mL 195.00CNY Detail
TCI America (H0089)  1,1,1,3,3,3-Hexamethyldisilazane  >96.0%(GC) 999-97-3 500mL 430.00CNY Detail
Alfa Aesar (A15139)  Hexamethyldisilazane, 98+%    999-97-3 25ml 190.0CNY Detail
Alfa Aesar (A15139)  Hexamethyldisilazane, 98+%    999-97-3 100ml 322.0CNY Detail
Alfa Aesar (A15139)  Hexamethyldisilazane, 98+%    999-97-3 500ml 806.0CNY Detail
Alfa Aesar (A15139)  Hexamethyldisilazane, 98+%    999-97-3 2500ml 3210.0CNY Detail
Alfa Aesar (42039)  Hexamethyldisilazane, Electronic grade, 99+%    999-97-3 25g 290.0CNY Detail
Alfa Aesar (42039)  Hexamethyldisilazane, Electronic grade, 99+%    999-97-3 100g 312.0CNY Detail
Alfa Aesar (42039)  Hexamethyldisilazane, Electronic grade, 99+%    999-97-3 500g 1409.0CNY Detail
Alfa Aesar (L16519)  Hexamethyldisilazane, Electronic grade, 99+%    999-97-3 25ml 251.0CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name hexamethyldisilazane

1.2 Other means of identification

Product number -
Other names SILAZANE HMN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adhesives and sealant chemicals,CBI,Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:999-97-3 SDS

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 999-97-3