108446-63-5

Upstream product

• 92-91-1 biphenyl-4-acetaldehyde 
• 100-63-0 phenylhydrazine 

Downstream Products

• 21470-37-1 2-((1,1′-biphenyl)-4-yl)-1H-indole 
• 108446-64-6 3-([1,1’-biphenyl]-4-yl)-1-phenyl-1H-pyrazole-4-carboxaldehyde 
• 92-91-1 biphenyl-4-acetaldehyde 
• 108446-76-0 (E)-3-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-acrylic acid 
• 108446-71-5 2-(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-ylmethylene)-malonic acid 
• 1186197-15-8 C₃₂H₂₇N₂P 
• 1357384-09-8 2-{[[3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl]methylene]-hydrazono}-3-(β-D-glucopyranosyl)-4-phenyl-2,3-dihydrothiazole 
• 1357384-10-1 2-{2-[[[3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl]methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}-N'-(4-chlorobenzylidene)acetohydrazide 
• 1357384-12-3 D-galactose 2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-13-4 D-mannose 2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-14-5 D-xylose 2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-15-6 2,3,4,5,6-penta-O-acetyl-D-galactose-2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]-hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-16-7 2,3,4,5,6-penta-O-acetyl-D-mannose-2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]-hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 
• 1357384-17-8 2,3,4,5-tetra-O-acetyl-D-xylose-2-{2-[[(3-(biphenyl-3-yl)-1-phenyl-1H-pyrazol-4-yl)methylene]-hydrazono]-4-phenylthiazol-3(2H)-yl}acetohydrazone 

Relevant academic research and scientific papers

Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors

The major drawbacks of P-glycoprotein (P-gp) inhibitors at the clinical stage make the development of new P-gp inhibitors challenging and desirable. In this study, we reported our structure-activity relationship studies of 4-indolyl quinazoline, which led to the discovery of a highly effective and orally active P-gp inhibitor, YS-370. YS-370 effectively reversed multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 bound directly to P-gp, did not alter expression or subcellular localization of P-gp in SW620/AD300 cells, but increased the intracellular accumulation of paclitaxel. Furthermore, YS-370 stimulated the P-gp ATPase activity and had moderate inhibition against CYP3A4. Significantly, oral administration of YS-370 in combination with paclitaxel achieved much stronger antitumor activity in a xenograft model bearing SW620/Ad300 cells than either drug alone. Taken together, our data demonstrate that YS-370 is a promising P-gp inhibitor capable of overcoming MDR and represents a unique scaffold for the development of new P-gp inhibitors.

Pyrazole-4-carboxylic Acids from Vanadium-catalyzed Chemical Transformation of Pyrazole-4-carbaldehydes

The conversion of aldehydes into carboxylic acids using oxidizing agents is a common protocol in transformation chemistry. An efficient oxidation strategy of transformation of pyrazole-4-aldehydes to the corresponding acids using vanadium catalysts in the presence of 30% H2O2 as an oxidant is described. The catalytic technology was successfully applied to a range of various 4-formylpyrazoles, and plausible mechanism is also discussed.

TEMPO-mediated Aza-diels-alder reaction: Synthesis of tetrahydropyridazines using ketohydrazones and olefins

A novel, facile, and efficient method for the synthesis of tetrahydropyridazines by a one-pot tandem reaction of easily accessible ketohydrazones and olefins in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) has been successfully developed. The reaction involves the initial generation of azoalkenes from direct oxidative dehydrogenation of ketohydrazones using TEMPO as the commercially available oxidant, followed by a subsequent aza-Diels-Alder reaction with olefins.

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.

Synthesis of pyrrol-2-yl- and pyrazol-4-ylmethylidene derivatives of betulin and allobetulin

Aldol-crotonic condensation of allobetulone and betulonic aldehyde with N-substituted pyrrole-2- and pyrazole-4-carbaldehydes afforded a series of new α,β-unsaturated ketones of lupane series. Their reduction provided 2-ylidene derivatives of allobetulin

Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions

A highly selective and efficient method for the synthesis of 5-trifluoromethylated and 5-perfluoroalkylated pyrazoles has been developed which relies on the cyclization of hydrazine dianions with ethyl perfluorocarboxylates. The pyrazoles prepared were ev

Oxidation of 2-arylindoles for synthesis of 2-arylbenzoxazinones with oxone as the sole oxidant

A novel and efficient method for the oxidation of 2-arylindoles to synthesize 2-arylbenzoxazinones utilizing oxone as the sole oxidant has been developed. The reaction tolerates a wide range of functional groups and allows quick and atom-economical assembly of a variety of valuable 2-arylbenzoxazinones in high yields.

2-Phenyl-indole derivatives and process for preparing the same

New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: STR1 wherein R represents a phenyl radical, an amino group, optionally substituted by an acetyl or benzoyl