108446-82-8Relevant academic research and scientific papers
A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl and 1,3-diarylpyrazol-4-yl propanoic acids
Jagath Reddy,Srinivasa Rao,Khalilullah,Thirupathaiah,Latha
, p. 423 - 426 (2008/02/10)
A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl (4a-h) and 1,3-diarylpyrazol-4-yl propanoic acids (5a-h) using Meldrum's acid (1) from the corresponding carboxaldehydes (2 & 3) is reported herein.
Functionally substituted 3-heterylpyrazoles: XI. 3-[3-Aryl(heteryl)pyrazol-4-yl]propenoic and propanoic acids
Bratenko,Chornous,Vovk
, p. 1171 - 1177 (2007/10/03)
3-Aryl(heteryl)-4-formylpyrazoles by condensation with malonic acid furnish 3-[3-aryl(heteryl)-pyrazol-4-yl]propenoic acids that in the presence of Raney nickel are reduced by hydrazine hydrate to 3-[3-aryl(heteryl)pyrazol-4-yl]propanoic acids. The succes
Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity
Bernard,Hulley,Molenda,Stochla,Wrzeciono
, p. 560 - 562 (2007/10/02)
beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.
