108461-91-2Relevant academic research and scientific papers
New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study
Li, Sin-Min,Tsai, Shuo-En,Chiang, Chia-Yin,Chung, Cheng-Yen,Chuang, Tsung-Jui,Tseng, Ching-Chun,Jiang, Wen-Ping,Huang, Guan-Jhong,Lin, Chin-Yu,Yang, Ya-Chen,Fuh, Mao-Tsu,Wong, Fung-Fuh
supporting information, (2020/10/21)
A new method was developed for synthesis of 1,2,4-triazole-3-carboxylates 5a–p and 6 from nitrilimines 3a–p through amination and heterocyclization two-steps reactions. All of 1,2,4-triazole-3-carboxylates 5 and 6 were characterized by spectroscopy techni
An Improved Synthesis of 1H-1,2,4-Triazoles from C-Triphenylphosphinimino-hydrazones
Bruche, Luca,Garanti, Luisa,Zecchi, Gaetano
, p. 772 - 774 (2007/10/02)
1-Phenyl-1H-1,2,4-triazoles 5a-h are prepared in good yields by reaction of the triphenylphosphine imide 1 with acyl chlorides 2a-h and subsequent base treatment of the intermediate phosphonium salts 3a-h.
