108472-20-4

Upstream product

• 108471-24-5 5-oxo-3-phenyl-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester 
• 53256-19-2 ethyl (Z)-3-amino-3-phenylacrylate 
• 33842-02-3 dichloromethylenedimethyliminium chloride 
• 108471-31-4 2-Dimethylamino-6-oxo-4-phenyl-6H-[1,3]oxazine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

SYNTHESES OF NEW 4-TRIFLUOROMETHYLATED 1,3-OXAZIN-6-ONES FROM THE ENAMINE OF ETHYL TRIFLUOROACETOACETATE

New 4-trifluoromethyl-1,3-oxazin-6-ones have been prepared in excellent yields form ethyl 3-amino-4,4,4-trifluorocrotonate (ATFC) by two original procedures: reaction of ATFC with phosgeniminium chlorides to give 2-dialkylamino-4-trifluoromethyl-1,3-oxazin-6-ones, or action of chlorinating agents on N-acyl ATFC.The reactivity of ATFC in these reactions is compared with non-fluorinated analogs.

The Vilsmeier-Haack Reaction of Isoxazolin-5-ones. Synthesis and Reactivity of 2-(Dialkylamino)-1,3-oxazin-6-ones

The Vilsmeier-Haack reaction on isoxazolin-5-ones gives 2-(dialkylamino)-1,3-oxazin-6-ones, and a reaction path is proposed depending on substitution pattern of the isoxazolin-5-ones studied.A thermal equilibrium between the oxazinones, imino ketenes, and vinyl isocyanates is hypothesized to explain most of the chemical reactivity of the 2-(dialkylamino)-1,3-oxazin-6-ones.