53256-19-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester is used as a building block for the synthesis of various pharmaceuticals, particularly peptide-based drugs. Its unique structure allows for the creation of new drug candidates and protein-based therapeutics.
Used in Research and Development:
(2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester is utilized in the research and development of new materials and compounds with potential biological and therapeutic applications. Its versatility and reactivity make it a valuable tool in advancing pharmaceutical and medical research.
Used in Organic Chemistry:
(2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester is used as a reagent in various organic chemistry reactions, enabling the synthesis of complex organic molecules and contributing to the discovery of novel compounds with potential applications in various industries.

Upstream product

• 129207-82-5 ethyl trans-3-phenyl-4,5-dihydro-5-(2-hydroxyphenyl)-4-isoxazolecarboxylate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 141-78-6 ethyl acetate 
• 100-47-0 benzonitrile 
• 141-97-9 ethyl acetoacetate 
• 625-28-5 Isovaleronitrile 
• 105-36-2 ethyl bromoacetate 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 
• 108-86-1 bromobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 698-16-8 benzohydroximoyl chloride 
• 6148-64-7 ethyl potassium malonate 

Downstream Products

• 53256-30-7 (E)-4-[1-Amino-1-phenyl-meth-(Z)-ylidene]-pent-2-enedioic acid diethyl ester 
• 60-80-0 antipyrine 
• 58787-21-6 ethyl 2-phenyl-4-methyl-3-pyridinecarboxylate 
• 161196-76-5 5-methoxy-4-methyl-2-phenylnicotinic acid ethyl ester 
• 54679-59-3 3-hydroxy-1-methyl-5-phenylpyrazole 
• 80030-92-8 2-methyl-5-phenyl-2,3-dihydro-1H-pyrazol-3-one 
• 402567-86-6 ethyl 2,4-diphenylthiazole-5-carboxylate 
• 6335-76-8 3-amino-3-phenylpropionic acid ethyl ester 
• 66092-09-9 diethyl 2,5-diphenyl-1H-pyrrole-3,4-dicarboxylate 
• 90788-49-1 2-phenyl-Δ²-pyrroline-4,5-dione 
• 90788-48-0 4-amino-2-oxo-4-phenyl-but-3-enoic acid 
• 90788-51-5 (Z)-4-Amino-2-oxo-4-phenyl-but-3-enoic acid ethyl ester 
• 1037824-80-8 (Z)-ethyl 2-(3,4,6-tri-O-benzyl-2-deoxy-2-nitro-β-D-glucopyranosyl)-3-amino-3-phenylacrylate 

Relevant academic research and scientific papers

Trifluoroethanol as a Unique Additive for the Chemoselective Electrooxidation of Enamines to Access Unsymmetrically Substituted NH-Pyrroles

An electrochemical method for the synthesis of unsymmetrically substituted NH-pyrroles is described. The synthetic strategy comprises a challenging heterocoupling between two structurally diverse enamines via sequential chemoselective oxidation, addition,

A kind of benzofuran and benzofuran coumarin derivative and its preparation method and application (by machine translation)

The invention discloses a formula (I), (II), (III), (IV) shown benzofurans and Coumestans derivative and its preparation method, and said styrene and furan and Coumestans derivative compound in the treatment of multi-drug resistant tuberculosis disease in the application. The invention surfactant and furan and Coumestans derivatives are a class of novel structure, the bacteriostatic effect is prominent anti-Mycobacterium tuberculosis compound, it is to Mycobacterium tuberculosis pks13 gene fragment encoding polyketide synthase as the acting target, inhibit the growth and reproduction of microorganisms, in particular inhibiting Mycobacterium tuberculosis in bacterial cell wall synthesis of branch, in the medical field has potential application prospect. (by machine translation)

Cu-Catalyzed Denitrogenative Transannulation of 3-Aminoindazoles to Assemble 1-Aminoisoquinolines and 3-Aminobenzothiophenes

We disclose a novel Cu-catalyzed denitrogenative transannulation of 3-aminoindazoles to afford diverse functionalized 3-aminobenzothiophenes and 1-aminoisoquinolines, in which denitrogenative transannulation of 3-aminoindazoles is reported for the first t

Lewis Acid-Mediated [3+3] Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives

A direct and single-step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid-promoted [3+3] annulation between 3-ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope. (Figure presented.).

Copper-Catalyzed One-pot Synthesis of Pyrimidines from Amides, N,N′-dimethylformamide dimethylacetal, and Enamines

A versatile copper catalyzed one-pot synthesis of diversely substituted pyrimidines directly from amides, N,N′-dimethylformamide dimethylacetal (DMF?DMA) and enamines has been established. The reaction involved the two C?N bonds and one C?C bond formation by formal [2+1+3] annulation approach to pyrimidines. This protocol is based on the use of readily available primary amides, DMF?DMA and enamines to install di- and tri-substituted pyrimidine structure with diverse functionality in one-pot manner, which makes this strategy to be appealing for the medicinal chemistry. (Figure presented.).

Novel photosensitized cyclization reactions of ethyl 3-amino-3-phenyl-2- propenoate derivatives to highly substituted pyrroles

Irradiation of nitrogen-saturated acetonitrile solutions containing ethyl 3-amino-3-phenyl-2-propenoate derivatives with the (Z)-configuration [(Z)- 1] and 10-methylacridinium perchlorate (MAP) at wavelengths longer than 340 nm afforded the corresponding pyrrole derivatives in good to high yields without exhibiting a profound effect related to the substituents. An analysis of the Stern-Volmer plots for the fluorescence quenching of MAP by (Z)-1 showed that this sensitizer fluorescence is efficiently quenched, and hence electron transfer is confirmed to be involved in the primary process of the MAPsensitized cyclization reactions of 1.

IBX mediated reaction of β-enamino esters with allylic alcohols: A one pot metal free domino approach to functionalized pyridines

IBX facilitated the reaction of β-enamino esters with allylic alcohols affording a direct, one-pot and metal free synthesis of functionalized pyridines including 2-substituted nicotinic acids, densely substituted pyridines and precursors of azafluorenones. The methodology also afforded the racemic pyridine core of cyclothiazomycin.

Simple conversion of enamines to 2h-azirines and their rearrangements under thermal conditions

A variety of substituted enamine derivatives were first found to be conveniently converted to the corresponding 2H-azirines mediated by phenyliodine (III) diacetate (PIDA). The formed 2-aryl-2W-azirines could be applied in the synthesis of indole-3-carbon

INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE

The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these comp

Development of practical rhodium phosphine catalysts for the hydrogenation of β-dehydroamino acid derivatives

The rhodium-catalyzed asymmetric hydrogenation of various β-dehydroamino acid derivatives to give optically active β-amino acids has been examined. Chiral monodentate 4,5-dihydro-3H-dinaphthophosphepines, which are easily tuned and accessible in a multi-10-g scale, have been used as ligands. The enantioselectivity is largely dependent on the nature of the substituent at the phosphorous atom and on the structure of the substrate. Applying optimized conditions up to 94% ee was achieved.