108473-00-3

Upstream product

• 1917-45-9 2,4-diaminopteridin-6-one 
• 213739-01-6 2,4-bis(N,N-dimethylaminomethyleneamino)pteridin-6-one 
• 1422390-71-3 2,4-bis(N,N-dimethylaminomethyleneamino)-6-benzenesulfonyloxypteridine 
• 1426333-64-3 2,4-bis(N,N-dimethylaminomethyleneamino)-6-(phenylethynyl)pteridine 
• 17231-51-5 2-amino-5-bromo-3-cyanopyrazine 
• 25911-65-3 2-amino-3-pyrazinonitrile 
• 50-01-1 guanidine hydrochloride 
• 108472-96-4 2-amino-3-cyano-5-(phenylethynyl)pyrazine 

Downstream Products

• 108473-04-7 6-(phenylethynyl)pterin 

Relevant academic research and scientific papers

Preparation of 6-ethynylpteridine derivatives by Sonogashira coupling

Sonogashira coupling of 6-sulfonyloxypteridine with various acetylenes is reported. Hydrolysis of the protecting groups with 1M NH3 gave the 6-subustituted 2,4-diaminopteridine while hydrolysis with 1M NaOH gave the 6-subsituted pterin.

Pteridines. 51. A New and Unequivocal Route to C-6 Carbon-Substituted Pterins and Pteridines

Coupling of terminal acetylenes with 2-amino-3-cyano-5-bromopyrazine in the presence of catalytic amounts of palladium(II) salts and Cu(I) gave a series of 5-ethynyl derivatives which were cyclized with guanidine to 2,4-diamino-6-ethynyl-substituted pteri