1084812-45-2

Basic information

• Product Name: 3-chloro-6-(difluoromethoxy)pyridazine
• Synonyms: 3-chloro-6-(difluoromethoxy)pyridazine
• CAS NO: 1084812-45-2
• Molecular Weight: 180.541
• Mol File: 1084812-45-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 275.3±35.0 °C(Predicted)
• Density: 1.466±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-chloro-6-(difluoromethoxy)pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-6-(difluoromethoxy)pyridazine(1084812-45-2)
• EPA Substance Registry System: 3-chloro-6-(difluoromethoxy)pyridazine(1084812-45-2)

Safety Data

• Hazardous Substances Data: 1084812-45-2(Hazardous Substances Data)

Upstream product

• 19064-67-6 6-chloro-2H-pyridazin-3-one 
• 1717-59-5 2,2-difluoro-2-(fluorosulfonyl)acetic acid 
• 1885-46-7 trifluoromethanesulfonic acid difluoromethyl ether 
• 19064-67-6 3-chloro-6-hydroxypyridazine 

Downstream Products

• 1084810-69-4 8-(6-(difluoromethoxy)pyridazin-3-yl)-5-(3,5-difluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine 
• 1084812-40-7 C₂₇H₂₀F₄N₄O₆S 

Relevant articles and documents

Tri- and difluoromethoxylated N-based heterocycles ? Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

The preparation of F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid and the evaluation of their biological activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate. To allow a facile access to the second F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also ?pyrazoles, ?pyrazine, ?pyridazine, and ?quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities.

ARYLQUINAZOLINES

The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation.