1084889-57-5Relevant articles and documents
Synthesis of glycyrrhetic acid derivatives
Yong,Wang,Aisa,Liu
, p. 194 - 196 (2008)
11-Deoxyglycyrrhetinic acid (DGA) (2) was produced by Clemmensen reduction of the C-11 carbonyl of 18β-glycyrrhetic acid (GA) (1). Four derivatives of GA and DGA (3a-3d) were synthesized. Their structures were elucidated using spectral data (IR, mass, su
Pentacyclic triterpenoid glycyrrhetinic acid derivative as well as preparation method and application thereof
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Paragraph 0046; 0054; 0063, (2020/05/01)
The invention discloses a pentacyclic triterpenoid glycyrrhetinic acid derivative which has a structure as shown in a general formula 1 or a formula 7 in the specification, wherein each substituent isdefined in detail in the specification. The invention also discloses application of the pentacyclic triterpenoid glycyrrhetinic acid derivative in preparation of anti-HCV drugs. Huh7 cytotoxic activity results show that the pentacyclic triterpenoid glycyrrhetinic acid derivative is low in cytotoxicity and has research value. In-vitro anti-HCVcc result shows that glycyrrhetinic acid has relativelyweak anti-HCVcc activity, but the pentacyclic triterpenoid glycyrrhetinic acid derivative has relatively good anti-HCV activity.