108498-50-6

Basic information

• Product Name: 2-[(furan-2-ylmethyl)sulfinyl]-N-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}acetamide
• CAS NO: 108498-50-6
• Molecular Formula: C₂₂H₃₀N₂O₄S
• Molecular Weight: 418.5496
• Mol File: 108498-50-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 675.2°C at 760 mmHg
• Flash Point: 362.1°C
• Density: 1.226g/cm³
• Vapor Pressure: 4.35E-18mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 2-[(furan-2-ylmethyl)sulfinyl]-N-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(furan-2-ylmethyl)sulfinyl]-N-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}acetamide(108498-50-6)
• EPA Substance Registry System: 2-[(furan-2-ylmethyl)sulfinyl]-N-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}acetamide(108498-50-6)

Safety Data

• Hazardous Substances Data: 108498-50-6(Hazardous Substances Data)

Usage

Chemical class

Sulfinyl acetamide derivative

Explanation

The compound contains a sulfinyl group (R2S) bonded to an acetamide group.

Explanation

The compound has a furan-2-ylmethyl group attached to a sulfur atom and a piperidin-1-ylmethyl group attached to a phenoxypropyl chain.

Explanation

The sulfur atom in the compound is connected to both a furan ring and a piperidine ring, which are key structural features.

Explanation

The acetamide group is part of the compound and is connected to a phenoxypropyl chain, which may contribute to its bioactive properties.
5. Potential pharmaceutical applications

Explanation

Due to its structural features, the compound may have bioactive properties and could be explored for its pharmacological effects or as a lead compound for drug development.
6. Further research and testing required

Explanation

To determine the specific therapeutic potential of the compound, additional research and testing would be necessary.

Functional groups

Furan-2-ylmethyl and piperidin-1-ylmethyl

Chemical structure

Sulfur atom bonded to a furan ring and a piperidine ring

Acetamide group

Attached to a phenoxypropyl chain

Upstream product

• 110-89-4 piperidine 
• 123855-56-1 N-[3-(3-formylphenoxy)propyl]-2-(furfurylsulfinyl)acetamide 
• 108441-34-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>chloroacetamide 
• 98-02-2 2-thiolomethyl-furan 
• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 
• 108441-41-4 N-{3-[3-(piperidinomethyl)phenoxy]propyl)-2-(furfurylthio)acetamide 

Relevant articles and documents

A novel histamine 2(H2) receptor antagonist with gastroprotective activity. I. Synthesis and pharmacological evaluation of N- phenoxypropylacetamide derivatives with thioether function

In an attempt to develop new types of anti-ulcer agents, a series of N- (phenoxypropyl)acetamide derivatives with a thioether moiety and their sulfur-oxidized analogues were synthesized and evaluated for histamine H2- receptor antagonistic activity, Ca antagonistic activity and gastric anti- secretory activity in the lumen-perfuseed rat. Selected compounds were also tested for gastroprotective activity, which was expected to be based on Ca antagonistic activity. Structure-activity relationships are discussed. As a thioether moiety, -CH2-S(O)p-CH2-Ar (Ar; phenyl or furyl) was found to be optimal for the above activities. Especially, N-[3-[(3-(piperidinomethyl) phenoxy]propyl]acetamide with a benzyl sulfinyl, benzylsulfonyl, furfurylsulfinyl or furfuryisulfonyl group showed potent gastroprotective activity upon oral administration in a rat model. These compounds are candidates for novel anti-ulcer drugs with gastric anti-secretory and gastroprotective activities. 2-Furfurylsulfinyl-N-[3- [(piperidinomethyl)phenoxy]propyl]-acetamide was the most potent among the compounds tested and was given the code designation FRG-8701.

ALKYLAMIDE DERIVATIVES WITH H2-RECEPTOR ANTAGONISTIC AND CYTOPROTECTIVE ACTION

Alkylamide derivatives having the formula, These compounds have a strong antiulcer action depend on histamine H 2-receptor antagonistic action and a cytoprotective action upon gastric mucous membrance.